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- Target Alle Ataxin 3 (ATXN3) Antikörper anzeigen
- Ataxin 3 (ATXN3)
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser Ataxin 3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Aufreinigung
- The antibody was purified by affinity chromatography.
- Klon
- 1H9-2
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product ATXN3 Primärantikörper
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anti-Ataxin 3 (ATXN3) (AA 1-364) antibody
ATXN3 Reaktivität: Human WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Ataxin 3 (ATXN3) (AA 261-288) antibodyATXN3 Reaktivität: Human WB, IHC (p), FACS Wirt: Kaninchen Polyclonal RB23951 unconjugated
anti-Ataxin 3 (ATXN3) antibodyATXN3 Reaktivität: Human WB, IHC (p), IP Wirt: Kaninchen Polyclonal unconjugated
anti-Ataxin 3 (ATXN3) (AA 1-288) antibodyATXN3 Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Ataxin 3 (ATXN3) antibodyKO Validated ATXN3 Reaktivität: Human WB, IF, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Ataxin 3 (ATXN3) (AA 267-297), (Middle Region) antibodyATXN3 Reaktivität: Human WB, IHC (p), FACS, EIA Wirt: Kaninchen Polyclonal unconjugated
anti-Ataxin 3 (ATXN3) antibodyATXN3 Reaktivität: Human ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Ataxin 3 (ATXN3) antibodyATXN3 Reaktivität: Human, Maus, Ratte IF Wirt: Kaninchen Polyclonal unconjugated
anti-Ataxin 3 (ATXN3) (AA 29-59) antibodyATXN3 Reaktivität: Human IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Ataxin 3 (ATXN3) (N-Term) antibodyATXN3 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schaf, Pferd, Kaninchen, Meerschweinchen, Hund, Zebrafisch (Danio rerio) WB Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 0.5 mg/mL
- Buffer
- phosphate-buffered solution, pH 7.2, containing 0.05 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Upon receipt, store undiluted between 2°C and 8°C.
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- Target
- Ataxin 3 (ATXN3)
- Andere Bezeichnung
- Ataxin-3 (ATXN3 Produkte)
- Synonyme
- Mjd antikoerper, zgc:56323 antikoerper, ATXN3 antikoerper, at3 antikoerper, jos antikoerper, mjd antikoerper, atx3 antikoerper, mjd1 antikoerper, sca3 antikoerper, ataxin-3 antikoerper, MJD1 antikoerper, MGC83584 antikoerper, AT3 antikoerper, ATX3 antikoerper, JOS antikoerper, MJD antikoerper, SCA3 antikoerper, 2210008M02Rik antikoerper, AI463012 antikoerper, AI647473 antikoerper, Sca3 antikoerper, Rsca3 antikoerper, ataxin 3 antikoerper, ataxin 3 L homeolog antikoerper, ataxin-3 antikoerper, atxn3 antikoerper, ATXN3 antikoerper, atxn3.L antikoerper, MICPUN_104046 antikoerper, MICPUCDRAFT_46658 antikoerper, Atxn3 antikoerper
- Hintergrund
- Ataxin-3 is an ubiquitously expressed protein which contains a poly-glutamine tract. Genetically abnormal expansion of the poly-glutamine repeats results in accumulation of ubiquitinated ataxin-3 protein aggregates and leads to a neurodegenerative disorder, Machado-Joseph disease (MJD). The protein has ubiquitin interacting motifs and a N-terminal Cysteine residue (C14) responsible for its deubiquitinating activity. Ataxin-3 binds and hydrolyzes polyubiquitinated proteins, and interacts with key proteasome components, such as p97/VCP and p45, indicating that Ataxin-3 may play functional roles in ubiquitin-proteasome system. The protein also act as a transcriptional repressor when interacting with transcriptional activators and coactivators.
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