Interleukin 33 Antikörper (IL33) (AA 112-270)

Details for Product anti-IL33 Antibody No. ABIN2665497, Anbieter: Anmelden zum Anzeigen
Antigen
  • IL33
  • C9orf26
  • DVS27
  • IL1F11
  • NF-HEV
  • NFEHEV
  • RP11-575C20.2
  • 9230117N10Rik
  • Il-33
  • Il1f11
  • RGD1311155
  • interleukin 33
  • IL33
  • Il33
Epitop
AA 112-270
69
26
20
15
12
7
6
5
5
4
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Reaktivität
Human
291
107
48
8
4
3
2
2
Wirt
Ziege
191
133
23
23
4
3
2
1
1
Klonalität (Klon)
Polyklonal ()
Konjugat
Dieser Interleukin 33 Antikörper ist unkonjugiert
36
19
14
14
8
7
5
5
5
4
4
4
3
3
3
3
3
3
3
3
3
3
1
1
1
1
1
1
1
Applikation
Flow Cytometry (FACS), Immunohistochemistry (IHC)
282
216
89
60
45
24
21
21
16
14
13
11
7
5
5
4
4
3
3
2
2
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Immunogen AA 112-270 (Accession# NM_033439) was expressed in E. coli.
Klon Poly5163
Isotyp Ig Fraction, IgG
Kreuzreaktivität (Details) In sandwich ELISA, no cross-reactivity with mouse or rat IL-33.
Reinigung The antibody was purified by antigen affinity chromatography.
Andere Bezeichnung IL-33 (IL33 Antibody Abstract)
Hintergrund IL-33, also known as NFHEV and DVS 27, is a 30 kD proinflammatory protein that belongs to IL-1 superfamily. IL-33 is constitutively expressed in smooth muscle and airway epithelia. It is upregulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1α or IL-1β stimulation. IL-33 interacts with IL1RL1/ST2 receptor and IL-1 receptor accessory protein (IL1RAP) in order to activate intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. Recombinant IL-33 has been shown to enhance Th2-associated immune responses and potently increase mast cell proliferation and cytokine production.
Pathways Production of Molecular Mediator of Immune Response
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Do not freeze.
Lagerung 4 °C
Informationen zur Lagerung The antibody solution should be stored undiluted between 2°C and 8°C.
Bilder des Herstellers
ELISA image for anti-Interleukin 33 (IL33) (AA 112-270) antibody (ABIN2665497) anti-Interleukin 33 (IL33) (AA 112-270) antibody
Allgemeine Veröffentlichungen McLaren, Michael, Salter, Ashlin, Calder, Miller, Liew, Ramji: "IL-33 reduces macrophage foam cell formation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 2, pp. 1222-9, 2010 (PubMed).

Schmitz, Owyang, Oldham, Song, Murphy, McClanahan, Zurawski, Moshrefi, Qin, Li, Gorman, Bazan, Kastelein: "IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines." in: Immunity, Vol. 23, Issue 5, pp. 479-90, 2005 (PubMed).

Onda, Kasuya, Takakura, Hori, Imaizumi, Takeuchi, Inoue, Takeda: "Identification of genes differentially expressed in canine vasospastic cerebral arteries after subarachnoid hemorrhage." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 19, Issue 11, pp. 1279-88, 1999 (PubMed).

Haben Sie etwas anderes gesucht?