TICAM2 Antikörper
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- Target Alle TICAM2 Antikörper anzeigen
- TICAM2 (Toll-Like Receptor Adaptor Molecule 2 (TICAM2))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser TICAM2 Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS)
- Aufreinigung
- The antibody was purified by affinity chromatography.
- Klon
- 9G1B30
- Isotyp
- IgG2a kappa
- Top Product
- Discover our top product TICAM2 Primärantikörper
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anti-Toll-Like Receptor Adaptor Molecule 2 (TICAM2) (C-Term) antibody
TICAM2 Reaktivität: Human, Maus, Ratte WB, ICC, IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 2 (TICAM2) (AA 1-235) antibodyTICAM2 Reaktivität: Human ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 2 (TICAM2) (AA 1-235) antibodyTICAM2 Reaktivität: Human WB, IP Wirt: Kaninchen Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 2 (TICAM2) (AA 150-200) antibodyTICAM2 Reaktivität: Human, Maus, Ratte, Affe, Rind (Kuh), Opossum WB, IHC, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 2 (TICAM2) (AA 87-103) antibodyTICAM2 Reaktivität: Human, Maus, Ratte, Hund, Pferd, Schimpanse, Makake WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 2 (TICAM2) (C-Term) antibodyTICAM2 Reaktivität: Human, Maus, Ratte WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 2 (TICAM2) (AA 12-41), (N-Term) antibodyTICAM2 Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB34146 unconjugated
anti-Toll-Like Receptor Adaptor Molecule 2 (TICAM2) (AA 1-235) antibodyTICAM2 Reaktivität: Human WB Wirt: Maus Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 2 (TICAM2) (AA 34-241) antibodyTICAM2 Reaktivität: Human WB, IHC, ICC Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 0.5 mg/mL
- Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- Target
- TICAM2 (Toll-Like Receptor Adaptor Molecule 2 (TICAM2))
- Andere Bezeichnung
- TICAM-2 (TICAM2 Produkte)
- Synonyme
- MyD88-4 antikoerper, TICAM-2 antikoerper, TIRAP3 antikoerper, TIRP antikoerper, TRAM antikoerper, B430113A10 antikoerper, Tirp antikoerper, Trif antikoerper, toll like receptor adaptor molecule 2 antikoerper, toll-like receptor adaptor molecule 2 antikoerper, TICAM2 antikoerper, Ticam2 antikoerper
- Hintergrund
- TICAM-2, also known as TRIF-related adaptor molecule (TRAM), is a TIR domain containing protein that was found to act as an adaptor molecule during LPS-induced innate immune response. Upon infection by Gram-negative bacteria, TLR4 specifically recognizes LPS and leads to the dimerization of the cytoplasmic TIR domains. The activated TLR4 subsequently recruits the adaptor protein complex containing both TICAM-1 and TICAM-2, resulting in the activation of IFN response factors and production of pro-inflammatory cytokines. In this signaling cascade, TICAM-2 is essential for bridging the interaction between TLR4 and TICAM-1. TICAM-2 is also involved in the regulation of the IL-18 signaling pathway, acting as a sorting adaptor that recruits MYD88 from the cytosol to the membrane region upon activation of IL-1/IL-18 receptors.
- Pathways
- TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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