Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C) Antikörper

Antigen: Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C)

Synonyme: BAFFR, CD268, BAFF-R, MGC138235, RGD1560810, TNFRSF13C

Klonalität: Monoklonal (11C1)

Wirt: Maus

Reaktivität: Human

Applikation: Durchflusszytometrie (FACS), Immunhistochemie (Paraffinschnitte) (IHC (p))

Produktnummer: ABIN266492

Produktbeschreibung

Weitere Bezeichnung: CD268 / BAFFR

Gen-ID: 115650

Immunogen: Tissue / cell preparation (Human) - human BAFF Receptor transfected mouse B celllymphoma L1.2 cells.

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: 11C1

Beschreibung: B cell-activating factor receptor (BAFF-R) is a 19 kD type III membrane protein. Itbelongs to TNFR superfamily, also known as TNFRSF member 13C (TNFRSF13C),BAFF receptor 3 (BR3), or CD268. BAFF-R is expressed on mature B cells, B celllymphoma, and T cell subset. BAFF-R is the major receptor for BAFF/BLys (or TALL-1,THANK) which binds to TACI and BCMA as well. The interaction of BAFF with BAFF-Rpromotes NF-ê, B activation and plays predominant roles in B-cell maturationand survival as well as costimulates T cell activation and proliferation. TRAF3 is aBAFF-R intracellularly associated protein, which negatively regulates BAFF-R-mediatedNF-ê, B activation. Alternate Names: anti-CD268 antibody, TNFRSF13C antibody, BR3 antibo.

Spezifität: Species Reactivity: Cross-reacts with Human. Not yet tested in other species.

Anwendungen

Applikationshinweise: Suggested working dilutions: Immunohistochemistry-Paraffin 1ug/0.1ml. Positive Controls: Mature B-Cells, B cell lymphoma, T-Cell subset

Konzentration: 1 mg/ml

Buffer: PBS, pH 7.2. Preservative: 0.09% sodium azide.

Lagerung: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.

Forschungsgebiet: Apoptose/Nekrose, Rezeptoren

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Immunohistochemistry staining of human tonsil with ABIN266492, showing intense staining of B cell follicles and weaker staining on GC. Magnification X200.

FACS analysis of B cells performed by gating on CD19+ B cells from tonsil.