CCR5 Antikörper (C-C Chemokine Receptor Type 5) (FITC)

Details for Product anti-CCR5 Antibody No. ABIN2661552, Anbieter: Anmelden zum Anzeigen
Antigen
  • CC-CKR-5
  • CCCKR5
  • CCR-5
  • CD195
  • CKR-5
  • CKR5
  • CMKBR5
  • IDDM22
  • Ckr5
  • Cmkbr5
  • CCR1-L
  • GPCR
  • CCR5
  • AM4-7
  • CCR5-L
  • chemokine (C-C motif) receptor 5 (gene/pseudogene)
  • chemokine (C-C motif) receptor 5
  • chemokine (C-C motif) receptor 2
  • C-C chemokine receptor type 5-like
  • CCR5
  • Ccr5
  • CCR2
  • LOC100399144
Reaktivität
Human
475
81
66
14
14
3
2
1
1
1
1
1
Wirt
Ratte
229
182
71
15
14
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser CCR5 Antikörper ist konjugiert mit FITC
43
26
20
19
16
14
13
13
9
9
9
6
6
5
5
5
5
4
4
4
4
4
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
Applikation
Intracellular Flow Cytometry (ICFC)
304
209
141
66
64
57
57
33
29
18
14
12
8
7
6
5
4
4
3
2
2
2
2
2
1
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
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Klon HEK-1-85a
Isotyp IgG2a kappa
Reinigung The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC.
Andere Bezeichnung CD195 (CCR5 Antibody Abstract)
Hintergrund CD195, also known as CCR5, is a 45 kD G protein-coupled seven transmembrane CC-chemokine receptor. It binds to MIP-1α, MIP-1β, and RANTES and is expressed on a subset of T cells and monocytes. CD195 mediates an intracellular signal thought to induce cell differentiation and proliferation. CCR5 has also been shown to act as a co-receptor for R5 HIV-1 cell entry, modification of CCR5 by sulfation contributes to the efficiency of HIV-1 entry. Recent studies have shown CCR5 to play a role in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.
Pathways Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Protect from prolonged exposure to light. Do not freeze.
Lagerung 4 °C
Informationen zur Lagerung The antibody solution should be stored undiluted between 2°C and 8°C.
Bilder des Herstellers
Flow Cytometry (FACS) image for anti-C-C Chemokine Receptor Type 5 (CCR5) antibody (FITC) (ABIN2661552) anti-C-C Chemokine Receptor Type 5 (CCR5) antibody (FITC)
Allgemeine Veröffentlichungen Liu, Dominska-Ngowe, Dykxhoorn: "Target silencing of components of the conserved oligomeric Golgi complex impairs HIV-1 replication." in: Virus research, Vol. 192, pp. 92-102, 2014 (PubMed).

Osman, Bhuyan, Hashimoto, Nasser, Maekawa, Suzu: "M-CSF inhibits anti-HIV-1 activity of IL-32, but they enhance M2-like phenotypes of macrophages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 11, pp. 5083-9, 2014 (PubMed).

Al-ofi, Coffelt, Anumba: "Monocyte subpopulations from pre-eclamptic patients are abnormally skewed and exhibit exaggerated responses to Toll-like receptor ligands." in: PLoS ONE, Vol. 7, Issue 7, pp. e42217, 2012 (PubMed).

Vaday, Peehl, Kadam, Lawrence: "Expression of CCL5 (RANTES) and CCR5 in prostate cancer." in: The Prostate, Vol. 66, Issue 2, pp. 124-34, 2005 (PubMed).

Lai, Yang, Douglas, Wang, Riedel, Ho: "Quantification of CCR5 mRNA in human lymphocytes and macrophages by real-time reverse transcriptase PCR assay." in: Clinical and diagnostic laboratory immunology, Vol. 10, Issue 6, pp. 1123-8, 2003 (PubMed).

Mañes, Mira, Colomer, Montero, Real, Gómez-Moutón, Jiménez-Baranda, Garzón, Lacalle, Harshman, Ruíz, Martínez-A: "CCR5 expression influences the progression of human breast cancer in a p53-dependent manner." in: The Journal of experimental medicine, Vol. 198, Issue 9, pp. 1381-9, 2003 (PubMed).

Mueller, Kelly, Strange: "Pathways for internalization and recycling of the chemokine receptor CCR5." in: Blood, Vol. 99, Issue 3, pp. 785-91, 2002 (PubMed).

Combadiere, Ahuja, Tiffany, Murphy: "Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES." in: Journal of leukocyte biology, Vol. 60, Issue 1, pp. 147-52, 1996 (PubMed).

Deng, Liu, Ellmeier, Choe, Unutmaz, Burkhart, Di Marzio, Marmon, Sutton, Hill, Davis, Peiper, Schall, Littman, Landau: "Identification of a major co-receptor for primary isolates of HIV-1." in: Nature, Vol. 381, Issue 6584, pp. 661-6, 1996 (PubMed).

Samson, Labbe, Mollereau, Vassart, Parmentier: "Molecular cloning and functional expression of a new human CC-chemokine receptor gene." in: Biochemistry, Vol. 35, Issue 11, pp. 3362-7, 1996 (PubMed).

Raport, Gosling, Schweickart, Gray, Charo: "Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha." in: The Journal of biological chemistry, Vol. 271, Issue 29, pp. 17161-6, 1996 (PubMed).

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