Interleukin 33 Antikörper (IL33) (Ser109) (Biotin)

Details for Product anti-IL33 Antibody No. ABIN2661329, Anbieter: Anmelden zum Anzeigen
Antigen
  • IL33
  • C9orf26
  • DVS27
  • IL1F11
  • NF-HEV
  • NFEHEV
  • RP11-575C20.2
  • 9230117N10Rik
  • Il-33
  • Il1f11
  • RGD1311155
  • interleukin 33
  • IL33
  • Il33
Epitop
Ser109
70
26
20
15
12
7
6
5
5
4
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Reaktivität
Maus, Ratte (Rattus)
292
106
47
8
4
3
2
2
Wirt
Ziege
191
133
23
23
4
3
2
1
1
Klonalität (Klon)
Polyklonal ()
Konjugat
Dieser Interleukin 33 Antikörper ist konjugiert mit Biotin
35
19
14
14
12
7
5
5
5
4
4
3
3
3
3
3
3
3
3
3
3
1
1
1
1
1
1
1
Applikation
Flow Cytometry (FACS)
282
216
90
60
45
24
21
21
16
14
13
11
7
5
5
4
4
3
3
2
2
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Ser109-Isoleucin266 (Accession# NM_133775) was expressed in E. coli.
Klon Poly5165
Isotyp Ig Fraction, IgG
Kreuzreaktivität Ratte (Rattus)
Reinigung The antibody was purified by antigen affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
Andere Bezeichnung IL-33 (IL33 Antibody Abstract)
Hintergrund IL-33 belongs to the IL-1 family and is closely related in structure to IL-18 and IL-1b. IL-33, IL-1b, and IL-18 are synthesized as biologically inactive precursor and are cleaved by the enzyme caspase-1 to be secreted as active mature forms. IL-33 stimulates target cells by binding to the IL-1R/TLR superfamily member ST2 and subsequently activates NF-κB and MAPK pathways via identical signalling events to those observed for IL-1b. In addition, IL-33 is a nuclear factor (NF-HEV) abundantly expressed in high endothelial venules from lymphoid organs that associates with chromatin and exhibits transcriptional regulatory properties.
Pathways Production of Molecular Mediator of Immune Response
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 0.2 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 1 % BSA and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Do not freeze.
Lagerung 4 °C
Informationen zur Lagerung The antibody solution should be stored undiluted between 2°C and 8°C.
Bilder des Herstellers
ELISA image for anti-Interleukin 33 (IL33) (Ser109) antibody (Biotin) (ABIN2661329) anti-Interleukin 33 (IL33) (Ser109) antibody (Biotin)
Allgemeine Veröffentlichungen Gao, Wang, Yang, Zhao, Wen, Li, Lu, Qin, Qi, Xie, Jiang, Wu, Zhang, Chen, Turnquist, Zhu, Lu: "Tumoral expression of IL-33 inhibits tumor growth and modifies the tumor microenvironment through CD8+ T and NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 1, pp. 438-45, 2014 (PubMed).

Arend, Palmer, Gabay: "IL-1, IL-18, and IL-33 families of cytokines." in: Immunological reviews, Vol. 223, pp. 20-38, 2008 (PubMed).

Moussion, Ortega, Girard: "The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'?" in: PLoS ONE, Vol. 3, Issue 10, pp. e3331, 2008 (PubMed).

Suzukawa, Iikura, Koketsu, Nagase, Tamura, Komiya, Nakae, Matsushima, Ohta, Yamamoto, Yamaguchi: "An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 9, pp. 5981-9, 2008 (PubMed).

Schmitz, Owyang, Oldham, Song, Murphy, McClanahan, Zurawski, Moshrefi, Qin, Li, Gorman, Bazan, Kastelein: "IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines." in: Immunity, Vol. 23, Issue 5, pp. 479-90, 2005 (PubMed).

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