CRLF2 Antikörper (Biotin)

Produktnummer ABIN2661304

Produktdetails anti-CRLF2 Antikörper (Biotin)

Target: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CRLF2 Antikörper ist konjugiert mit Biotin

Applikation: Immunohistochemistry (IHC), Flow Cytometry (FACS)

Aufreinigung: The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.

Klon: 1B4

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu CRLF2

Target: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Andere Bezeichnung: TSLPR (CRLF2 Produkte)

Synonyme: CRLF2 antikoerper, CRL2 antikoerper, CRLF2Y antikoerper, TSLPR antikoerper, CRLM2 antikoerper, Ly114 antikoerper, Tpte2 antikoerper, Tslpr antikoerper, Crl2 antikoerper, cytokine receptor like factor 2 antikoerper, cytokine receptor-like factor 2 antikoerper, CRLF2 antikoerper, Crlf2 antikoerper

Hintergrund: TSLP-R, also known as the thymic stromal lymphopoietin protein receptor, cytokine receptor-like 2, CRL2, and IL-XR, is a type I membrane receptor that forms a functional heterodimeric complex with IL-7R to bind with TSLP. The TSLP-R contains a WSXWS motif required for proper protein folding and a box1 motif important for association with the JAKs. TSLP-R has a predicted molecular weight approximately 40 kD, and has two isoforms reported that are produced by alternative splicing. The TSLP-R is expressed preferentially in myeloid cells, dendritic cells, and activated monocytes. It is weakly expressed in T cells. Expression has also been reported in heart, skeletal, muscle, and kidney tissues. TSLP binding to the heterodimeric functional receptor (TSLP-R and IL-7R) activates JAK2, STAT3, and STAT5 to stimulate cell proliferation. Ligand receptor interactions have been implicated in the development of the hematopoietic system, dendritic cell maturation, and the maintenance and polarization of human Th2 memory T cells in allergy diseases.