Interleukin 22 (IL22) (AA 34-179) Antikörper (Alexa Fluor 647)

Details zu Produkt Nr. ABIN2657957, Anbieter: Anmelden zum Anzeigen
Antigen
  • IL-21
  • IL-22
  • IL-D110
  • IL-TIF
  • ILTIF
  • TIFIL-23
  • TIFa
  • zcyto18
  • IL-22a
  • ILTIFa
  • Iltif
  • RGD1561292
  • interleukin-22
  • interleukin 22
  • IL22
  • il22
  • Il22
Epitop
AA 34-179
43
13
12
9
8
5
3
3
3
3
2
1
1
1
1
1
Reaktivität
Maus
222
120
35
2
2
2
2
1
1
1
1
1
Wirt
Ziege
133
106
50
13
Klonalität (Klon)
Polyklonal ()
Konjugat
Alexa Fluor 647
32
17
14
12
10
9
9
8
8
7
6
6
6
6
6
6
6
3
3
3
3
2
1
1
1
1
1
1
1
1
1
Applikation
Flow Cytometry (FACS)
221
93
62
31
20
13
11
8
6
5
3
3
2
2
2
2
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen AA 34-179 (Accession# NM_016971), was expressed in E. coli.
Klon Poly5164
Isotyp IgG
Reinigung The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 647 under optimal conditions.
Andere Bezeichnung IL-22 (IL22 Antibody Abstract)
Hintergrund IL-22 is a cytokine structurally related to IL-10. Mouse IL-22 consists of 179 amino acids and has a predicted molecular weight of 20 kD. It is secreted primarily by Th17, Th1, Th2, lymphoid tissue inducer cells (LTi), and subsets of natural killer cells. It has been reported that aryl hydrocarbon receptor (AhR) expression is essential for the production of IL-22 by TCRγδ T cells. AhR activation increases Th17 polarization and induces IL-22 production. IL-22 functions by engaging the heterodimeric IL-22 receptor (IL-22R) complex, consisting of two receptor subunits, IL-22R1 and IL-10Rβ. IL-22 acts on nonhematopoietic tissue cells, such as epithelial cells of the digestive and respiratory systems and keratinocytes of the skin. IL-22 is involved in inflammatory processes such as dermal inflammation, psoriasis, inflammatory bowel disease, hepatitis, and Crohn's disease. Moreover, it plays a critical role in mucosal immunity and the wound healing process.
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Protect from prolonged exposure to light. Do not freeze.
Lagerung 4 °C
Informationen zur Lagerung The antibody solution should be stored undiluted between 2°C and 8°C
Bilder des Herstellers
Flow Cytometry (FACS) image for anti-Interleukin 22 (IL22) (AA 34-179) antibody (Alexa Fluor 647) (ABIN2657957) anti-Interleukin 22 (IL22) (AA 34-179) antibody (Alexa Fluor 647)
Allgemeine Veröffentlichungen Martin, Hirota, Cua, Stockinger, Veldhoen: "Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals." in: Immunity, Vol. 31, Issue 2, pp. 321-30, 2009 (PubMed).

Veldhoen, Hirota, Christensen, OGarra, Stockinger: "Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells." in: The Journal of experimental medicine, Vol. 206, Issue 1, pp. 43-9, 2009 (PubMed).

Wolk, Witte, Hoffmann, Doecke, Endesfelder, Asadullah, Sterry, Volk, Wittig, Sabat: "IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 9, pp. 5973-81, 2007 (PubMed).

Zheng, Danilenko, Valdez, Kasman, Eastham-Anderson, Wu, Ouyang: "Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis." in: Nature, Vol. 445, Issue 7128, pp. 648-51, 2007 (PubMed).

Liang, Tan, Luxenberg, Karim, Dunussi-Joannopoulos, Collins, Fouser: "Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides." in: The Journal of experimental medicine, Vol. 203, Issue 10, pp. 2271-9, 2006 (PubMed).

Dumoutier, Louahed, Renauld: "Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 4, pp. 1814-9, 2000 (PubMed).

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