Aflatoxin (AFT) Antikörper

Antigen: Aflatoxin (AFT)

Klonalität: Monoklonal (AFA-1)

Wirt: Maus

Applikation: Enzyme Immunoassay (EIA)

Produktnummer: ABIN265678

Produktbeschreibung

Weitere Bezeichnung: Aflatoxin

Immunogen: Purified Aflatoxin B1.

Isotyp: IgG2a  (Passende Sekundärantikörper)

Klon: AFA-1

Beschreibung: The aflatoxins are a group of closely related mycotoxins that are widely distributed innature. The most important of the group is aflatoxin B1 (AFB1), which has a range ofbiological activities, including acute toxicity, teratogenicity, mutagenicity andcarcinogenicity. In order for AFB1 to exert its effects, it must be converted to its reactiveepoxide by the action of the mixed function mono-oxygenase enzyme systems(cytochrome P450-dependent) in the tissues (in particular, the liver) of the affectedanimal. This epoxide is highly reactive and can form derivatives with several cellularmacromolecules, including DNA, RNA and protein. Cytochrome P450 enzymes mayadditionally catalyse the hydroxylation (to AFQ1 and AFM1) and demethylation (toAFP1) of the parent AFB1 molecule, resulting in products less toxic than AFB1.Conjugation of AFB1 to glutathione (mediated by glutathione S-transferase) and itssubsequent excretion is regarded as an important detoxification pathway in animals.Aflatoxins are well recognized as a cause of liver cancer, but they have additionalimportant toxic effects. Aflatoxin B1 is a potent hepatocarcinogenic and mutagenicmycotoxin of Aspergillus flavus. Alternate Names: anti-FB1 antibody, anti-AFB1-AR1 antibody, anti-Aldoketoreductase 7 antibody.

Spezifität: This antibody recognizes Aflatoxin B1. Cross-reactivity with other aflatoxins is underinvestigation. Species Reactivity: Fungi.

Anwendungen

Applikationshinweise: Suggested working dilutions: Immunoassay 5 ug/ml

Buffer: PBS, pH7.4

Lagerung: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Forschungsgebiet: Toxine

Beschränkungen: Nur für Forschungszwecke einsetzbar