KRT16 Antikörper

Produktnummer ABIN265495

Produktdetails anti-KRT16 Antikörper

Target: KRT16 (Keratin 16 (KRT16))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KRT16 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects endogenous levels of Cytokeratin 16 protein. (region surroundign Ser451)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and RatSpecies reactivity (tested):Human.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000approx. 1/20000. Western Blot: 1/500approx. 1/1000. Immunohistochemistry: 1/50approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-KRT16 Antikörper (ABIN265495)

Yu, Ye, Zhong, Ding, Chen: "Effect of advanced oxidation protein products on articular cartilage and synovium in a rabbit osteoarthritis model." in: Orthopaedic surgery, Vol. 7, Issue 2, pp. 161-7, (2016) (PubMed).

Zhang, Han, Song, Luo, Jin, Mu, Su, Ji, Ren, Liu: "Interferon-? regulates the function of mesenchymal stem cells from oral lichen planus via indoleamine 2,3-dioxygenase activity." in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, Vol. 44, Issue 1, pp. 15-27, (2015) (PubMed).

Suga, Sugimura, Koshiishi, Yorifuji, Makino, Takeda: "Heparin/heparan sulfate/CD44-v3 enhances cell migration in term placenta-derived immortalized human trophoblast cells." in: Biology of reproduction, Vol. 86, Issue 5, pp. 134, 1-8, (2012) (PubMed).

Details zu KRT16

Target: KRT16 (Keratin 16 (KRT16))

Andere Bezeichnung: Cytokeratin 16 (KRT16 Produkte)

Synonyme: CK16 antikoerper, FNEPPK antikoerper, K16 antikoerper, K1CP antikoerper, KRT16A antikoerper, NEPPK antikoerper, AI324768 antikoerper, Krt1-16 antikoerper, Ka16 antikoerper, KRT16 antikoerper, Krt16 antikoerper, keratin 16 antikoerper, keratin 16, type I S homeolog antikoerper, keratin, type I cytoskeletal 16 antikoerper, KRT16 antikoerper, Krt16 antikoerper, krt16.S antikoerper, LOC101108147 antikoerper, LOC100714013 antikoerper

Hintergrund: Keratin 16 is expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation-related keratins). Keratin 16 is absent in normal breast tissue and in noninvasive breast carcinomas. Only 10 % of the invasive breast carcinomas show diffuse or focal positivity. Reportedly, a relatively high concordance was found between the carcinomas immunostaining with the basal cell and the hyperproliferation-related keratins, but not between these markers and the proliferation marker Ki-67. This supports the conclusion that basal cells in breast cancer may show extensive proliferation, and that absence of Ki-67 staining does not mean that (tumor) cells are not proliferating. Two cytokeratins, 6 and 16, are expressed when keratincytes are undergoing rapid turnover in various pathological states, wound healing, psoriasis and some carcinomasSynonyms: CK16, Cytokeratin-16, K16, KRT16, KRT16A, Keratin 16, Keratin type I cytoskeletal 16, Keratin-16

Molekulargewicht: approx. 52 kDa

Gen-ID: 3868

NCBI Accession: NP_005548

UniProt: P08779