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Gastrin Antikörper

GAST Reaktivität: Human, Maus, Ratte WB, IF, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN265432
  • Target Alle Gastrin (GAST) Antikörper anzeigen
    Gastrin (GAST)
    Reaktivität
    • 53
    • 32
    • 28
    • 6
    • 2
    • 1
    Human, Maus, Ratte
    Wirt
    • 55
    • 11
    • 1
    Kaninchen
    Klonalität
    • 56
    • 11
    Polyklonal
    Konjugat
    • 38
    • 9
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Gastrin Antikörper ist unkonjugiert
    Applikation
    • 54
    • 30
    • 25
    • 14
    • 13
    • 13
    • 12
    • 11
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    This antibody detects endogenous levels of Gastrin protein. (region surrounding Met90)
    Kreuzreaktivität (Details)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    Aufreinigung
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
    Reinheit
    > 95 % pure by SDS-PAGE
    Top Product
    Discover our top product GAST Primärantikörper
  • Applikationshinweise
    ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200. IF: 1: 50approx. 1: 200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    DO NOT FREEZE!
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C.
  • Target
    Gastrin (GAST)
    Andere Bezeichnung
    Gastrin (GAST Produkte)
    Synonyme
    GAS antikoerper, Gas antikoerper, PPG34 antikoerper, GAST antikoerper, gastrin antikoerper, GAST antikoerper, Gast antikoerper
    Hintergrund
    Gastrin, which is normally formed by mucosal cells in the gastric antrum and by the D cells of the pancreatic islets, is a hormone whose main function is to stimulate secretion of HCl by the gastric mucosa. HCl, in turn, inhibits gastrin formation. Gastrin also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. Gastrin is regulated by epidermal growth factor in both mice and humans. Gastrin is excreted in excess by pancreatic tumors in the Zollinger- Ellison syndrome. Gastrin maps to human chromosome 17q-21. Gastrin- Releasing Peptide (GRP) stimulates the release of gastrin as well as other gastrointestinal hormones, in addition to acting as an autocrine growth factor for certain cell types. High levels of GRP are found in the human lung just after birth and levels decrease thereafter in parallel with the observed disease in a number of pulmonary neuroendocrine cells. GRP is known to promote lung tumorigenesis in model systems and, interestingly, is induced by retinoic acid. GRP is involved in several functions with the hypothalamus,and is thought to play a role in regulating pituitary hormone secretion. GRP maps to human chromosome 18q21.Synonyms: GAS, GAST
    Molekulargewicht
    approx. 12 kDa
    Gen-ID
    2520
    NCBI Accession
    NP_000796
    UniProt
    P01350
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