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UBE2V1 Antikörper (C-Term)

UBE2V1 Reaktivität: Human, Maus, Ratte WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN265158
  • Target Alle UBE2V1 Antikörper anzeigen
    UBE2V1 (Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1))
    Bindungsspezifität
    • 16
    • 11
    • 8
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 53
    • 21
    • 20
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 50
    • 3
    Kaninchen
    Klonalität
    • 53
    Polyklonal
    Konjugat
    • 17
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser UBE2V1 Antikörper ist unkonjugiert
    Applikation
    • 41
    • 21
    • 14
    • 13
    • 13
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Spezifität
    This antibody detetcs UEV1A. UE1A is one of seven named isoforms of UEV1. UEV1A is located in the nucleus, while iosforms 3 and 5 are found in the membrane (7). This antibody may also recognize other isoforms of UEV1A.
    Aufreinigung
    Purified
    Immunogen
    Peptide corresponding to 15 amino acids near the C-terminus of human UEV1A
    Isotyp
    IgG
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    Discover our top product UBE2V1 Primärantikörper
  • Applikationshinweise
    Western Blot: 1 to 2 μg/mL. Postive Control: Jurkat Cell Lysate.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    Phosphate buffered saline with 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
  • Target
    UBE2V1 (Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1))
    Andere Bezeichnung
    UBE2V1 / CROC1 (UBE2V1 Produkte)
    Synonyme
    CIR1 antikoerper, CROC-1 antikoerper, CROC1 antikoerper, UBE2V antikoerper, UEV-1 antikoerper, UEV1 antikoerper, UEV1A antikoerper, 0610011J09Rik antikoerper, AI256840 antikoerper, D7Bwg1382e antikoerper, CROC-1B antikoerper, ubiquitin conjugating enzyme E2 V1 antikoerper, ubiquitin-conjugating enzyme E2 variant 1 antikoerper, UBE2V1 antikoerper, ube2v1 antikoerper, Ube2v1 antikoerper
    Hintergrund
    Ubiquitin-conjugating enzyme E2 (UEV1) was initially discovered as a protein similar in sequence and structure to the E2 ubiquitin-conjugating enzymes but lacking their enzymatic activity (1). There are at least two variants and multiple isoforms of UEV1. In particular, UEV1A (Ubiquitin-conjugating enzyme E2 variant 1 isoform A) has recently been shown to be an important component of the Toll-like receptor and IL-1R signaling pathway (reviewed in 2). Signals from these pathways are relayed by a number of downstream molecules such as MyD88 and tumor necrosis factor receptor associated factor (TRAF6), ultimately activating various kinases and transcription factors (2,3). UEV1A is part of a dimeric ubiquitin-conjugating enzyme complex also containing Ubc13 (ubiquitin-conjugating enzyme 13) that together with TRAF6 activates TAK1, a member of the mitogen-activated protein kinase kinase kinase family (4-6). The Ubc13-UEV1A complex also mediates the Lys-63 ubiquitination of TRAF-6, and this ubiquitination is essential for TAK1 activation (5).Synonyms: CROC-1, P/OKcl.19, TRAF6-regulated IKK activator 1 beta Uev1A, UBE2V, UEV-1, UEV1, Ubiquitin-conjugating enzyme E2 variant 1
    Gen-ID
    387522
    NCBI Accession
    NP_001027459
    UniProt
    Q13404
    Pathways
    T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades
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