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MTA2 Antikörper (AA 652-668)

MTA2 Reaktivität: Human, Maus, Ratte WB, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN265128
  • Target Alle MTA2 Antikörper anzeigen
    MTA2 (Metastasis Associated 1 Family, Member 2 (MTA2))
    Bindungsspezifität
    • 7
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 652-668
    Reaktivität
    • 44
    • 31
    • 28
    • 10
    • 9
    • 9
    • 9
    • 7
    • 7
    • 6
    • 5
    • 5
    • 4
    • 2
    • 1
    Human, Maus, Ratte
    Wirt
    • 43
    • 4
    Kaninchen
    Klonalität
    • 42
    • 5
    Polyklonal
    Konjugat
    • 33
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MTA2 Antikörper ist unkonjugiert
    Applikation
    • 47
    • 13
    • 10
    • 9
    • 7
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Spezifität
    This antibody reacts to MTA2 / PID. No cross response to MTA1.
    Aufreinigung
    Purified
    Immunogen
    Rabbit polyclonal PID antibody was raised against a synthetic peptide corresponding to amino acids 652 to 668 of human PID/MTA2 (6), which differ from the mouse sequence by one amino acid (7).
    Isotyp
    IgG
    Top Product
    Discover our top product MTA2 Primärantikörper
  • Applikationshinweise
    Western Blot: 0.5 to 1 μg/mL, a 75 kDa band can be detected. Tissue Expression: Widely expressed, located in the nucleus. Positive Control: HeLa cell lysate. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    Phosphate buffered saline with 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
  • Target
    MTA2 (Metastasis Associated 1 Family, Member 2 (MTA2))
    Andere Bezeichnung
    MTA2 (MTA2 Produkte)
    Synonyme
    MTA1L1 antikoerper, PID antikoerper, fd61b05 antikoerper, wu:fd61b05 antikoerper, wu:fi29g02 antikoerper, zgc:63487 antikoerper, pid antikoerper, mta1l1 antikoerper, MTA2 antikoerper, DKFZp470E0911 antikoerper, AW550797 antikoerper, Mata1l1 antikoerper, Mta1l1 antikoerper, mmta2 antikoerper, metastasis associated 1 family member 2 antikoerper, metastasis associated 1 family, member 2 antikoerper, metastasis-associated gene family, member 2 antikoerper, metastasis associated 1 family member 2 L homeolog antikoerper, MTA2 antikoerper, mta2 antikoerper, Mta2 antikoerper, mta2.L antikoerper
    Hintergrund
    The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 pathway, including Chk2 , p53R2 (2), p53AIP1 (3), Noxa (4), PIDD (5), and PID/MTA2 (6), were recently discovered. The transcriptional activity of p53 is modulated by protein stability and acetylation. PID/MTA2, also termed MTA1-L1, was found to be a subunit of nucleosome remodeling and deacetylating (NRD/NuRD) complex (6 - 8). PID/MTA2 modulates the enzymatic activity of the histone deacetylase complex and its expression reduces the levels of acetylated p53. Deacetylation of p53 by PID/MTA2 represses p53-dependent transcriptional activation and modulates p53-mediated cell growth arrest and apoptosis (6). PID/MTA2 is ubiquitously expressed in human tissues (8).Synonyms: MTA1-L1, MTA1L1, Metastasis-associated 1-like 1, Metastasis-associated protein MTA2, PID, p53 target protein in deacetylase complex
    Gen-ID
    9219
    NCBI Accession
    NP_004730
    UniProt
    O94776
    Pathways
    Chromatin Binding
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