PPAP2C Antikörper

Produktnummer ABIN265044

Produktdetails anti-PPAP2C Antikörper

Target: PPAP2C (Phosphatidic Acid Phosphatase Type 2C (PPAP2C))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPAP2C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody reacts to Lyosphospholipid Phosphatase (LPP) 2.

Aufreinigung: Purified

Immunogen: Unique peptide derived from the human lysophospholipid phosphatase 2 protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 10 - 15 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Details zu PPAP2C

Target: PPAP2C (Phosphatidic Acid Phosphatase Type 2C (PPAP2C))

Andere Bezeichnung: PPAP2C / LPP2 (PPAP2C Produkte)

Synonyme: fj16e10 antikoerper, wu:fj16e10 antikoerper, zgc:66434 antikoerper, ppap2c antikoerper, MGC75849 antikoerper, MGC81169 antikoerper, LPP2 antikoerper, PAP-2c antikoerper, PAP2-g antikoerper, Lpp2 antikoerper, phospholipid phosphatase 2b antikoerper, phospholipid phosphatase 2 antikoerper, phospholipid phosphatase 2 S homeolog antikoerper, phosphatidic acid phosphatase type 2C antikoerper, plpp2b antikoerper, plpp2 antikoerper, plpp2.S antikoerper, PLPP2 antikoerper, Plpp2 antikoerper, PPAP2C antikoerper

Hintergrund: Phosphatidic acid phosphatase type 2 (PAP2) was originally identified as a plasma membrane enzyme that catalyses the dephosphorylation of the putative second messenger, phosphatidic acid (PA) to diacylglycerol (DG) [1]. Subsequently, multiple isoforms of PAP2 were cloned [2-5]. It was found that these enzymes dephosphorylate a number of lipid phosphates in vitro other than PA, including the potent bioactive lipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Therefore, they have been renamed lipid phosphate phosphatases (LPPs). Currently, there are four members of this family called LPP1, LPP1a, LPP2 and LPP3 [6]. S1P [7] and LPA [8] regulate the proliferation, differentiation, apoptosis and migration of cells by binding to a family of G protein-coupled receptors. Thus, EDG1/S1P1, EDG3/S1P3, EDG5/S1P2/AGR16/H218, EDG6/S1P4 and EDG8/S1P5/nrg-1 are high affinity S1P receptors [7] whereas EDG2/LPA1, EDG4/LPA2 and EDG7/LPA3 have high affinity for LPA [8]. Recently, the over-expression of LPP1 was shown to limit LPA-stimulated signalling in Rat2 fibroblasts [9] and LPA-stimulated DNA synthesis in HEK 293 cells [10]. Similarly, over-expression of LPP1, LPP1a and LPP2 attenuate S1P-signalling to the p42/p44 mitogen activated protein kinase cascade [11].Synonyms: Lipid phosphate phosphohydrolase 2, PAP2-gamma, Phosphatidate phosphohydrolase type 2c, Phosphatidic acid phosphatase 2c

Gen-ID: 8612

NCBI Accession: NP_003703

UniProt: O43688