CACNG4 Antikörper

Produktnummer ABIN265042

Produktdetails anti-CACNG4 Antikörper

Target: CACNG4 (Calcium Channel, Voltage-Dependent, gamma Subunit 4 (CACNG4))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CACNG4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody reacts to CACNG4.

Aufreinigung: Purified

Immunogen: Synthetic peptide derived from the rat calcium channel gamma4 subunit conjugated to KLH

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 5- 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Details zu CACNG4

Target: CACNG4 (Calcium Channel, Voltage-Dependent, gamma Subunit 4 (CACNG4))

Andere Bezeichnung: CACNG4 (CACNG4 Produkte)

Synonyme: CACNG4 antikoerper, AI413107 antikoerper, AW491861 antikoerper, calcium voltage-gated channel auxiliary subunit gamma 4 antikoerper, calcium channel, voltage-dependent, gamma subunit 4 antikoerper, CACNG4 antikoerper, Cacng4 antikoerper

Hintergrund: Voltage-dependent calcium channels (VDCCs) are large (>400 kDa) heteromers which contain, minimally, three core subunits alpha1, alpha2/delta, beta in a 1:1:1 stoichiometry1. Expression of VDCC gene products in Xenopus oocytes, or transfected cells shows that the alpha1 subunits contain the ion channel pore while the auxiliary alpha2/delta and beta subunits confer optimal cell surface expression and channel kinetics. Until recently, the only exception to the above paradigm was the skeletal muscle VDCC, which, in addition to the alpha1, alpha2/delta, beta core motif, also has an additional tightly associated integral membrane glycoprotein subunit termed gamma 1. Upon co-expression with the alpha1.1, alpha2/delta1, beta1a subunits of the skeletal muscle VDCC, gamma subunits alter the peak currents, and the kinetics of channel activation and inactivation with the overall effect being a normalisation of currents to those resembling the endogenous channel. Together, these results suggest that gamma subunits modulate skeletal muscle VDCCs by stabilising their conformation. The gamma 4 subunit is specifically localized in the brain, with the gamma 2 and gamma 3 subunits. It shares >60 % sequence homology with the gamma 2 and gamma 3 subunits and ~25 % sequence homology with the gamma 1 and gamma 5 subunits.Synonyms: Neuronal voltage-gated calcium channel gamma-4 subunit, Voltage-dependent calcium channel gamma-4 subunit

Gen-ID: 27092

NCBI Accession: NP_055220

UniProt: Q9UBN1