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BACE1 Antikörper (AA 485-501)

BACE1 Reaktivität: Human, Maus WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN264995
  • Target Alle BACE1 Antikörper anzeigen
    BACE1 (Beta-secretase 1 (BACE1))
    Bindungsspezifität
    • 16
    • 13
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 485-501
    Reaktivität
    • 82
    • 51
    • 41
    • 7
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 76
    • 11
    Kaninchen
    Klonalität
    • 71
    • 16
    Polyklonal
    Konjugat
    • 56
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser BACE1 Antikörper ist unkonjugiert
    Applikation
    • 64
    • 37
    • 29
    • 18
    • 14
    • 13
    • 13
    • 11
    • 11
    • 7
    • 3
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB)
    Spezifität
    This antibody Detects BACE (CT).
    Aufreinigung
    Purified
    Immunogen
    Synthetic peptide corresponding to amino acids 485 to 501 of Human BACE.
    Isotyp
    IgG
    Top Product
    Discover our top product BACE1 Primärantikörper
  • Applikationshinweise
    Western Blot: 0.5-1.0 μg/mL. Detects an approximately 70 kDa band. Positive Control: Human brain tissue lysate.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    Phosphate buffered saline solution containing 0.02 % Sodium Azide as a preservative
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
  • Target
    BACE1 (Beta-secretase 1 (BACE1))
    Andere Bezeichnung
    BACE1 (BACE1 Produkte)
    Synonyme
    ASP2 antikoerper, BACE antikoerper, HSPC104 antikoerper, C76936 antikoerper, Bace antikoerper, MGC145931 antikoerper, BACE1 antikoerper, zgc:77409 antikoerper, beta-secretase 1 antikoerper, beta-site APP cleaving enzyme 1 antikoerper, beta-site APP-cleaving enzyme 1 antikoerper, BACE1 antikoerper, Bace1 antikoerper, bace1 antikoerper
    Hintergrund
    BACE1 is a protease responsible for the proteolytic processing of the amyloid precursor protein (APP). Amyloid beta peptide is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimers disease. This peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease termed beta-secretase (BACE), of which there are two isoforms, BACE1 and 2. This enzyme is synthesized as a propeptide that must be modified to the mature and active form by the prohormone convertase furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP and a membrane-bound remnant. This remnant is then processed by another protease termed gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide.Synonyms: ASP2, Aspartyl protease 2, BACE, BACE-1, Beta-secretase 1, Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1, KIAA1149, Memapsin-2, Membrane-associated aspartic protease 2
    Gen-ID
    23621
    NCBI Accession
    NP_036236
    UniProt
    P56817
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