In den Warenkorb
Bestellen Sie auch über:
+49 (0)241 95 163 153
+49 (0)241 95 163 155

Death Effector Domain Containing 2 (DEDD2) Antikörper

Antigen

Death Effector Domain Containing 2 (DEDD2)
Synonyme FLAME-3, DEDD2, MGC140424, MGC145883, DEFT, KE05, DEDD1, FLDED1, CASP8IP1, 2410050E11Rik, DEDD, MGC127710, DKFZp459K109
Klonalität Polyklonal
Wirt
Alternativen

Kaninchen
Reaktivität
Alternativen

Human
Applikation
Alternativen Western Blot (WB)
Produktnummer ABIN264570
Menge 0.1 mg  (Varianten)
Preis 380,00 €   Zzgl. Versandkosten €20,00 und MWSt
Lieferung nach
Verfügbarkeit Lieferung in 7 bis 10 Werktagen

Produktbeschreibung
Anwendungen Alternativen Sekundärantikörper Varianten zurück nach oben

Produktmerkmale Synonyms: FLAME3, FLAME-3, PSEC0004, FADD-like anti-apoptotic molecule 3, DEDD-2, DNA-bindingdeath effector domain-containing protein 2, DED-containing protein FLAME-3
Weitere Bezeichnung DEDD2
Swiss-Prot Q8WXF8
Immunogen Synthetic peptide corresponding to 11 amino acids near the amino terminus of HumanDEDD2
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Beschreibung Apoptotic signals are often triggered by cell surface death receptors throughprotein-protein interactions mediated by conserved domains such as the death effectordomain. A novel death effector domain (DED)-containing protein, DEDD2, has been recentlyidentified. Over-expression of DEDD2 in transfected cells induces moderate apoptosis andresults in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. Morerecently, it has been shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP butnot FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to thenucleus upon induction of apoptosis, and it has been suggested that DEDD2 may targetcaspase-8 to the nucleus and that DEDD2 thus plays a critical role in deathreceptor-induced apoptosis. At least two alternatively spliced transcript variants encodingdistinct isoforms have been found for DEDD2.
Spezifität This antibody reacts to DEDD 2. Species: Human, Mouse, Rat. Others not tested.

Anwendungen
Alternativen Sekundärantikörper Varianten zurück nach oben

Applikationshinweise Western Blot: 0.5 - 1,0 ug/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Reinigung Aff - Purified
Buffer PBS containing 0.02% Sodium Azide
Lagerung Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.
Forschungsgebiet Apoptose/Nekrose, Todesrezeptoren
Beschränkungen Nur für Forschungszwecke einsetzbar

Alternativen
Anwendungen Sekundärantikörper Varianten zurück nach oben

Alternativen zu Antigen "Death Effector Domain Containing 2 (DEDD2)", Typ "Antikörper" finden
Wirte Kaninchen (35)
Reaktivitäten Human (29), Maus (22), Ratte (Rattus) (21), Rind (Kuh) (10), Hund (9), Huhn (4), Kaninchen (4), Pferd (3), Schwein (2), Schaf (1)
Applikationen Durchflusszytometrie (FACS) (17), Immunfluoreszenz (IF) (16), Western Blot (WB) (13), Immunhistochemie (Paraffinschnitte) (IHC (p)) (5), Immunpräzipitation (IP) (4), ELISA (3), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (3), Enzyme Immunoassay (EIA) (2), Dot Blot (Dot) (1), Immunoelectron Microscopy (IEM) (1), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)) (1)
Konjugate Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)