Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized withSynthetic peptide conjugated to ovalbumin derived from the C-terminus of CYP2A6 andmouse myeloma Ag8563 cells. Antigen identical in CYP2A6, 2A7 and 2A13.
CYP2A6
Reaktivität: Human
WB, ELISA, IF
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
ELISA. Immunohistochemistry on paraffin sections. Western Blot: 1 - 2 μg/mL. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Buffer
Phosphate buffered saline with 0.08 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Haltbarkeit
12 months
Target
CYP2A6
(Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 (CYP2A6))
CPA6 antikoerper, CYP2A antikoerper, CYP2A3 antikoerper, CYPIIA6 antikoerper, P450C2A antikoerper, P450PB antikoerper, cyp2a6 antikoerper, cytochrome P450 family 2 subfamily A member 6 antikoerper, cytochrome P450 2A6 antikoerper, cytochrome P450 family 2 subfamily A member 6 L homeolog antikoerper, CYP2A6 antikoerper, cyp2a6.L antikoerper
Hintergrund
The cytochrome P450 proteins (CYPs) are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP2A6 is a liver enzyme that metabolizes a number of drugs and a variety of procarcinogens, though it is primarily responsible for the metabolism of nicotine, the major addictive agent in tobacco. CYP2A6 inactivates nicotine to cotinine, and then cotinine to 3-hydroxycotinine. Differences in CYP2A6 genotypes are related to nicotine dependence, and may influence smoking habits and withdrawal symptoms in individuals that are quitting smoking. This suggests that an individualized smoking cessation program may be designed based on CYP2A6 genotypes.Synonyms: CYP2A3, CYPIIA3, CYPIIA6, Coumarin 7-hydroxylase, Cytochrome P450 2A6