Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B) Antikörper

Antigen: Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B)

Synonyme: DTL, BAFF, BLYS, CD257, TALL1, THANK, ZTNF4, TALL-1, TNFSF20, TNFSF13B, RGD1561519

Klonalität: Monoklonal (T7-241)

Wirt: Maus

Reaktivität: Human

Applikation: Enzyme Immunoassay (EIA), Durchflusszytometrie (FACS)

Produktnummer: ABIN262930

Produktbeschreibung

Weitere Bezeichnung: CD257 / BAFF

Gen-ID: 10673

Immunogen: recombinant human BAFF(TL7) protein.

Isotyp: IgG1

Klon: T7-241

Beschreibung: The T7-241 antibody recognizes human BAFF also known as B cell activating factor,tumor necrosis factor ligand superfamily 13B, B lymphocyte stimulator (BLYS), TNF andAPOL-related leukocyte expressed ligand 1 (TALL1), and TNF homolog that activatesapoptosis, NF- kappaB, and JNK (THANK). BAFF is a type II transmembrane protein,and a member of the tumor necrosis factor ligand superfamily. BAFF can beproteolytically cleaved to form a soluble protein. BAFF, like other TNF ligand familymembers, forms homotrimers. The predicted molecular weight of a BAFF monomer isapproximately 31 kD. BAFF is expressed on peripheral blood B and T lymphocytes,monocytes, macrophages, and dendritic cells and is upregulated by IFN- gamma anddownregulated by PMA/ionomycin treatment. The T7-241 antibody has been shown tobe useful for flow cytometry and ELISA. BAFF stimulates B and T cell immunity andregulates humoral immunity by binding TACI and BCMA receptors, BAFF preventsapoptosis and promotes B cell survival by binding the BAFF-specific receptor(BAFFR/BR3). The T7-241 antibody has been shown to be useful for flow cytometry andELISA. Alternate Names: anti-BAFF antibody, anti-BLYS antibody, anti-TNFSF13b antibody, anti-B cell activatingfactor antibody, anti-tumor necrosis factor ligand superfamily 13B antibody, anti-Blymphocyte stimulator (BLYS) antibody, anti-TNF and APOL-related leukocyteexpressed ligand 1 (TALL1) antibody, anti-TNF homolog that activates apoptosisantibody, anti-NF-kappa B and JNK (THANK) antibody.

Spezifität: Species Reactivity: Human.

Anwendungen

Applikationshinweise: Positive Controls: Peripheral blood B and T lymphocytes, monocytes, macrophages, dendritic cells.Upregulated by IFN- g

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Lagerung: Store at 4C. Do not freeze.

Forschungsgebiet: Apoptose/Nekrose

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Human peripheral blood lymphocytes stained with purified 122, followed by biotinylated anti-mouse IgG and Sav-PE