X-Box Binding Protein 1 (XBP1) Antikörper

Antigen: X-Box Binding Protein 1 (XBP1)

Synonyme: XBP2, TREB5, XBP-1, TREB-5, D11Ertd39e, cb918, treb5, trebf, xbp1a, xbp1b, id:ibd1195, wu:fb02h05, wu:fb63f10, HTF, xbp1, MGC53678, MGC130816, xbp2, xXBP1, MGC76163, XBP1, XBPP1, MGC127699

Klonalität: Polyklonal

Wirt: Huhn

Reaktivität: Human

Applikation: Western Blot (WB)

Produktnummer: ABIN262127

Produktbeschreibung

Weitere Bezeichnung: XBP1 / TREB5

Gen-ID: 7494

Swiss-Prot: P17861

Immunogen: The immunogen for this antibody was a sequence from 1a.a. to 74a.a. from XBP1(a261a.a. long protein).

Beschreibung: This protein is a transcription factor that regulates MHC class II genes by binding to apromoter element referred to as an X box. The protein contains two domains commonlyfound in transcription factors that confer DNA binding and dimerization capability. Thisprotein product was also separately identified as a cellular transcription factor that bindsto an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It mayincrease expression of viral proteins by acting as the DNA binding partner of a viraltransactivator. There is also a recent finding that the same agents that cause an ERstress response, the unfolded protein response, also increase transcription of this gene.This increase in transcription requires an ER stress response consensus bindingelement in the promoter. Adding to the list of functional possibilities is a recent reportfrom studies of knockout mice showing that this gene is essential for hepatocyte growth.A pseudogene has been identified and localized to chromosome 5. Alternate Names: anti-Tax responsive element binding protein 5 antibody, anti-TREB5 antibody, anti-Xbox binding protein 1 antibody, anti-XBP2 antibody.

Spezifität: Species Reactivity: This antibody is reactive against Human. Localization: Nuclear. Theoretical Molecular Weight: 28695 Da.

Anwendungen

Applikationshinweise: Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution:1:2000. Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signaldevelopment.

Buffer: Phosphate-Buffered Saline. Preservative: No Preservative.

Lagerung: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development. ( anti-XBP1 )