Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C) Antikörper

Antigen: Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C)

Synonyme: BAFFR, CD268, BAFF-R, MGC138235, RGD1560810, TNFRSF13C

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Immunhistochemie (Paraffinschnitte) (IHC (p)), Western Blot (WB)

Produktnummer: ABIN261036

Produktbeschreibung

Weitere Bezeichnung: CD268 / BAFFR

Gen-ID: 115650, 72049, 117029

Immunogen: Synthetic peptide corresponding to a region within the C-terminus of human CD268.

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptorfamily, and has the characteristic structure of a 7 transmembrane G protein-coupledreceptor (GPCR). CCR5 regulates trafficking and effector functions of memory/effectorTh1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligandsplay an important role in viral pathogenesis. CCR5 represents the co-receptor formacrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Together withthe CD4 binding receptor, CCR5 plays a critical role in HIV entry into the target cells.Moreover, the CCR5 ligands macrophage inflammatory protein (MIP)-1 alpha, MIP-1beta and RANTES act as endogenous inhibitors of HIV infection, making both CCR5and its chemokine ligands attractive therapeutic targets for HIV infection. Recent studieshave also highlighted the role of CCR5 in a variety of other human diseases, rangingfrom infectious and inflammatory diseases to cancer. Alternate Names: anti-AM4 7 antibody, anti-C C chemokine receptor type 5 antibody, anti-C C CKR 5antibody, anti-CC Chemokine Receptor Type 5 antibody, anti-CC CKR 5 antibody,anti-CCCKR 5 antibody, anti-CCCKR5 antibody, anti-CCR 5 antibody, anti-CCR5antibody, anti-CCR5 chemokine (C C motif) receptor 5 antibody, anti-CD 195 antibody,anti-CD195 antibody, anti-CD195 Antigen antibody, anti-Chemokine C C motif receptor5 antibody, anti-CHEMR13 antibody, anti-CKR 5 antibody, anti-CKR5 antibody,anti-CMKBR 5 antibody, anti-CMKBR5 antibody, anti-HIV 1 Fusion Coreceptor antibody,anti-HIV1 fusion coreceptor antibody.

Spezifität: Specific for human CD268, also known as B cell activating factor receptor (BAFF-R).CD268 is a member of the tumor necrosis factor receptor family, which is expressed byB cells. CD268 plays a role in BAFF induced B cell development and survival, and isthought to be involved in B cell autoimmune diseases.Detects a band approximately 20kDa in Western blots of human, mouse and rat spleenlysates. Species Reactivity: Human, Rat and Mouse.

Anwendungen

Applikationshinweise: Suggested working dilutions: Western Blot 2ug/ml - 5ug/ml,Immunohistochemistry-Paraffin

Konzentration: 1.0 mg/ml

Buffer: PBS. Preservative: 0.02% Sodium Azide

Lagerung: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Forschungsgebiet: Apoptose/Nekrose, Rezeptoren

Beschränkungen: Nur für Forschungszwecke einsetzbar