A Kinase (PRKA) Anchor Protein 12 (AKAP12) Antikörper

Antigen: A Kinase (PRKA) Anchor Protein 12 (AKAP12)

Synonyme: AKAP250, FLJ20945, FLJ97621, DKFZp686M0430, DKFZp686O0331, Srcs5, SSeCKS, Tsga12, AI317366, AKAP12A, AKAP12B, AKAP12G, AKAP12, esr1, sb:cb27, wu:fb72g12, wu:fc21c03, si:ch73-192g21.1

Klonalität: Polyklonal

Wirt: Ziege

Reaktivität: Human

Applikation: Western Blot (WB)

Produktnummer: ABIN260660

Produktbeschreibung

Weitere Bezeichnung: AKAP12

Immunogen: Peptide with the sequence C-KQERESAKSELTES from the C terminus of the proteinSequence according to the Entrez Gene accession number NP_005091.

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Gravin (also known as A Kinase Anchor Protein 12, AKAP12) was cloned from a cDNAexpression library screened with serum, from a myasthenia gravis patient. Antibodies toGravin were found in 22 out of 72 myasthemia gravis patients and absent in sera ofnormal individuals. This protein is a myristoylated high molecular weight cytoplasmicprotein expressed in endothelial cells, cultured fibroblasts and osteosarcoma cells andhighly expressed in the brain. Gravin can bind kinases like PKA and PKC by differentdomains of the protein and can localize these kinases to specific domains in the cell.Upon differentiation of NT2 cells to neurons (NT2 N), Gravin expression is up regulatedand enriched at the inner peripheral cortex in close proximity to the plasma membrane.In differentiated cells, gravin is co-localized with PKCbII, PKCa and PKA. Decreasedbinding of PKCa to gravin was found after activation of PKC. Alternate Names: anti-A kinase (PRKA) anchor protein (gravin) 12 antibody, anti-A kinase Anchor Protein12 antibody, anti-A kinase anchor protein 250kDa antibody, anti-AKAP 12 antibody,anti-AKAP 250 antibody, anti-AKAP12 antibody, anti-AKAP250 antibody,anti-DKFZp686M0430 antibody, anti-DKFZp686O0331 antibody, anti-Gercelin antibody,anti-Gravin antibody, anti-Kinase scaffold protein gravin antibody, anti-Myastheniagravis autoantigen gravin antibody, anti-Srcs5 antibody, anti-SSeCKS antibody,anti-Tsga12 antibody.

Spezifität: Gravin is a kinase anchoring protein thought to be involved in the localization of proteinkinase a and protein kinase C. Species Reactivity: Human.

Anwendungen

Buffer: Tris buffered saline. Preservative: 0.02% Sodium Azide.

Lagerung: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Forschungsgebiet: Chromatin und nukleäre Signaltransduktion, Zellzyklus, Kinasen/Phosphatasen, Neurologie

Beschränkungen: Nur für Forschungszwecke einsetzbar