T-Cell Receptor (TCR), gamma/delta- Antikörper

Antigen: T-Cell Receptor (TCR), gamma/delta-

Klonalität: Monoklonal (V65)

Wirt: Maus

Reaktivität: Ratte (Rattus)

Applikation: Immunhistochemie (Gefrierschnitte) (IHC (fro)), Durchflusszytometrie (FACS), Immunpräzipitation (IP)

Produktnummer: ABIN260026

Produktbeschreibung

Weitere Bezeichnung: T Cell Receptor (TCR) gamma/delta

Immunogen: CD3 +ve TCR alpha/beta -ve rat T cell hybridoma line.

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: V65

Beschreibung: The receptors on T cells consist of immunoglobulin like integral membrane glycoproteinscontaining 2 polypeptide subunits, alpha and beta, of similar molecular weight, 40 to 55kD in the human. Like the immunoglobulins of the B cells, each T cell receptor subunithas, external to the cell membrane, an N terminal variable domain and a C terminalconstant domain.T cell receptors recognise foreign antigens which have been processed as smallpeptides and bound to major histocompatibility complex molecules at the surface ofantigen presenting cells. Each T cell receptor is a dimer consisting of one alpha and onebeta chain or one delta and one gamma chain. In a single cell, the T cell receptor lociare rearranged and expressed in the order delta, gamma, beta, and alpha. If both deltaand gamma rearrangements produce functional chains, the cell expresses delta andgamma. If not, the cell proceeds to rearrange the beta and alpha loci. Alternate Names: anti-T cell antigen receptor delta polypeptide antibody, anti-T cell antigen receptorgamma polypeptide antibody, anti-T cell rearranging gene gamma antibody, anti-T cellreceptor delta antibody, anti-T cell receptor delta locus antibody, anti-T cell receptorgamma antibody, anti-T cell receptor gamma chain C region PT gamma 1/2 antibody,anti-T cell receptor gamma cluster antibody, anti-T cell receptor gamma locus antibody,anti-T cell receptor T3 delta chain antibody, anti-T cell receptors antibody, anti-T cellsurface glycoprotein CD3 delta chain antibody, anti-TCRD antibody, anti-TCRGantibody, anti-TRD antibody, anti-TRD locus antibody, anti-TRD@ antibody, anti-TRGantibody, anti-TRG locus antibody, anti-TRG@ antibody.

Spezifität: ABIN260026 recognises a constant determinant of the rat gamma/delta T cell receptor.This antibody stains all rat gamma/delta T cells, and also identifies as gamma/delta Tcells a population of dendritic epidermal T lymphocytes. It may be used to stimulate theproliferation of gamma/delta T cells in the presence of either IL-2 or IL-4. Species Reactivity: Rat. Not yet tested in other species. Localization: Type I membrane protein.

Anwendungen

Applikationshinweise: Suggested working dilutions: flow cytometry / FACS analysis 1/10 - 1/100,Immunohistochemistry-Frozen

Konzentration: 1.0 mg/ml

Buffer: Phosphate buffered saline pH7.2. Preservative: 0.09% Sodium Azide (NaN3).

Lagerung: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Forschungsgebiet: Immunologie, Rezeptoren, Signaltransduktion

Beschränkungen: Nur für Forschungszwecke einsetzbar