Sodium Channel, Nonvoltage-Gated 1, delta (SCNN1D) Antikörper

Antigen: Sodium Channel, Nonvoltage-Gated 1, delta (SCNN1D)

Synonyme: ENaCd, SCNED, dNaCh, ENaCdelta, MGC149710, MGC149711, Scnn1d, SCNN1D

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Immunhistochemie (Gefrierschnitte) (IHC (fro)), Western Blot (WB)

Produktnummer: ABIN259149

Produktbeschreibung

Weitere Bezeichnung: ENAC delta / SCNN1D

Gen-ID: 6339

Swiss-Prot: P51172

Immunogen: A synthetic peptide as a part of human amiloride-sensitive sodium channel subunit delta(SCNED, SCNN1D) conjugated to immunogenic carrier protein was used as theimmunogen.

Format: Serum

Beschreibung: SCNN1D is a subunit of the epithelial sodium channel (ENaC). ENaC has high sodiumselectivity, low conductance, and amiloride sensitivity. The epithelial Na(+) channel(ENaC) regulates Na(+) homeostasis in cells and across epithelia, in the kidney, lungand colon it plays an essential role in trans-epithelial sodium and fluid balance. ENaCalso mediates aldosterone-dependent sodium re-uptake in the distal nephron of thekidney, thus regulating blood pressure. Four homologous ENaC subunits (alpha, beta,gamma, and delta) have been isolated in mammals. Combination of alpha-, beta-, andgamma-subunits or delta-, beta-, and gamma-subunits forms fully functional channels. Adelta subunit can replace the alpha subunit. However, the pharmacology, sensitivity toamiloride, conductance, and ionic selectivity of the delta/beta-gamma channel aredifferent from those of the alpha/beta-gamma channel. FUNCTION: Sodium permeablenon-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates theelectrodiffusion of the luminal sodium (and water, which follows osmotically) through theapical membrane of epithelial cells. Controls the reabsorption of sodium in kidney,colon, lung and sweat glands. Also plays a role in taste perception. SUBUNIT:Heterotetramer of two alpha, one beta and one gamma subunit. A delta subunit canreplace the alpha subunit. SUBCELLULAR LOCATION: Membrane, Multi-passmembrane protein. Alternate Names: anti-Epithelial Na(+) channel subunit delta antibody, anti-delta-ENaC antibody,anti-nonvoltage-gated sodium channel 1 subunit delta antibody, anti-SCNED antibody,anti-delta-NaCH antibody, anti-dNaCh antibody, anti-ENaCdelta antibody,anti-MGC149710 antibody, anti-MGC149711 antibody, anti-DNACH antibody.

Spezifität: Appears to be specific for SCNN1D. Species Reactivity: Human. Localization: Membrane, multi-pass membrane protein.

Anwendungen

Applikationshinweise: Suggested working dilutions: Western Blot 1:300 to 1:4000

Buffer: Lyophilised in PBS. Preservative: No Preservative.

Lagerung: Store at 4C for short-term. Aliquot and store at -20C for long term. Avoid freeze-thawcycles.

Forschungsgebiet: Ionenkanäle

Beschränkungen: Nur für Forschungszwecke einsetzbar