V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK) (pTyr221) Antikörper

Antigen: V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK)

Synonyme: CRKII, Crk3, Crko, Crk-I, Crkol, Crk-II, CrkIII, Crk-III, fb34h10, fc05a01, fi19g05, wu:fb34h10, wu:fc05a01, wu:fc54a04, wu:fi19g05, zgc:100936, CRK

Epitope: pTyr221

Klonalität: Monoklonal (EPR269Y)

Wirt: Kaninchen

Reaktivität: Human

Applikation: Immunfluoreszenz (IF), Western Blot (WB)

Produktnummer: ABIN258943

Produktbeschreibung

Weitere Bezeichnung: CRK pTyr221

Gen-ID: 1398

Swiss-Prot: P46108

Immunogen: A phospho specific peptide corresponding to regions surrounding Tyrosine 221 wasused as an immunogen. This antibody detects proteins phosphorylated at Y221.

Isotyp: IgG  (Passende Sekundärantikörper)

Klon: EPR269Y

Beschreibung: Crk (p38) are adaptor proteins, composed mostly of SH2 and SH3 domains, which playa key role in cellular signaling by mediating the construction of protein complexes andalso by managing cell proliferation, differentiation, and migration (1). They are criticalintegrators of upstream signals for cell invasion and migration in human cancer celllines. Crk is believed to be a regulator of invasive responses because increased levelsof the protein have been observed in multiple human cancers (2). In vivo studies havedemonstrated that decreased levels of Crk remarkably inhibits tumor formation and itsinvasive growth (3). Crk associates with ERM family proteins (including ezrin, radixin,and moesin), activates RhoA, and promotes cell motility toward hyaluronic acid (4). Alternate Names: Anti-Adapter molecule crk antibody, Anti-Avian sarcoma virus CT10 (v crk) oncogenehomolog antibody, Anti-CRK antibody, Anti-CRKII antibody, Anti-CSAID Binding Protein1 antibody, Anti-CSAID binding protein antibody, Anti-CSBP 1 antibody, Anti-CSBP 2antibody, Anti-CSBP antibody, Anti-CSBP1 antibody, Anti-CSBP2 antibody, Anti-CSPB1 antibody, Anti-CSPB1 antibody, Anti-Cytokine suppressive anti inflammatory drugbinding protein antibody, Anti-EXIP antibody, Anti-MAP kinase MXI2 antibody, Anti-MAPkinase p38 alpha antibody, Anti-MAPK 14 antibody, Anti-MAPK14 antibody, Anti-MAXinteracting protein 2 antibody, Anti-Mitogen Activated Protein Kinase 14 antibody,Anti-Mitogen activated protein kinase p38 alpha antibody, Anti-Mxi 2 antibody, Anti-Mxi2antibody, Anti-p38 ALPHA antibody, Anti-p38 antibody, Anti-p38ALPHA antibody,Anti-PRKM14 antibody, Anti-PRKM15 antibody, Anti-Proto oncogene C crk antibody,Anti-RK antibody, Anti-SAPK 2A antibody, Anti-SAPK2A antibody, Anti-Stress ActivatedProtein Kinase 2A antibody, Anti-v crk avian sarcoma virus CT10 oncogene homologantibody, Anti-v crk sarcoma virus CT10 oncogene homolog antibody, Anti-v crksarcoma virus CT10 oncogene homolog (avian) antibody.

Spezifität: Species Reactivity: This antibody is reactive against Human. Not yet tested in other species.

Anwendungen

Applikationshinweise: Suggested working dilutions: Western Blot 1:1000-1:2000,Immunocytochemistry 1:50-1:100. Positive Controls: K562 cell lysate

Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol and 0.05% BSA. Preservative: 0.01% sodium azide.

Lagerung: Store at -20 Degree C.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Western blot analysis on K562 cell lysates using anti-Phospho-Crk/p38 (pY221) RabMAb 1:2000 dilution. Cells were either (A) untreated (B) treated with AP.