Catalase (CAT) Antikörper

Antigen: Catalase (CAT)

Synonyme: MGC138422, MGC138424, Cas1, Cs-1, Cas-1, 2210418N07, CS1, RATCATL, RATCAT01, fb68a12, wu:fb68a12, CAT, CATA, CT21282, DMCATHPO, DROCATHPO, U00145, bs36h11.y1, DmelCG6871, CG6871, MGC128112, CATALASE, CATALASE 2, T12J5.2, Cat, GB11648, catalase, MGC147040, DKFZp469E0232

Klonalität: Monoklonal (EP1929Y)

Wirt: Kaninchen

Reaktivität: Human, Maus, Ratte (Rattus)

Applikation: Immunhistochemie (Gefrierschnitte) (IHC (fro)), Immunfluoreszenz (IF), Western Blot (WB)

Produktnummer: ABIN258666

Produktbeschreibung

Weitere Bezeichnung: Catalase

Gen-ID: 847, 12359, 24248

Swiss-Prot: P04040

Isotyp: IgG  (Passende Sekundärantikörper)

Klon: EP1929Y

Beschreibung: Human catalase is an heme-containing peroxisomal enzyme that breaks down hydrogenperoxide to water and oxygen, it is implicated in ethanol metabolism, inflammation,apoptosis, aging and cancer. The 1.5A resolution human enzyme structure, both withand without bound NADPH, establishes the conserved features of mammalian catalasefold and assembly, implicates Tyr370 as the tyrosine radical, suggests the structuralbasis for redox-sensitive binding of cognate mRNA via the catalase NADPH binding site,and identifies an unexpectedly substantial number of water-mediated domain contacts(1). Because catalase has a low affinity for H2O2, it has been suggested thatglutathione peroxidase clears most H2O2 within the erthrocyte and that catalase is oflittle import. It has been hypothesized that erythrocyte catalase might function to protectheterologous somatic cells against challenge by high levels of exogenous H2O2 (e.g., inareas of inflamation) (2). Alternate Names: anti-Cas1 antibody, anti-CAT antibody, anti-Cs1 antibody.

Spezifität: A synthetic peptide corresponding to residues near the C-terminus of human Catalasewas used as an immunogen. Species Reactivity: Cross reacts with human, mouse and rat.

Synonyme: MGC138422, MGC138424, Cas1, Cs-1, Cas-1, 2210418N07, CS1, RATCATL, RATCAT01, fb68a12, wu:fb68a12, CAT, CATA, CT21282, DMCATHPO, DROCATHPO, U00145, bs36h11.y1, DmelCG6871, CG6871, MGC128112, CATALASE, CATALASE 2, T12J5.2, Cat, GB11648, catalase, MGC147040, DKFZp469E0232

Anwendungen

Applikationshinweise: Suggested working dilutions: immunohistochemistry 1:100 250,Western Blot 1:10000 - 20000,Immunocytochemistry 1:100 250. Positive Controls: HeLa cell lysate

Lagerung: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Forschungsgebiet: Krebs, Organelle, Hitzeschockproteine, Zell-/Gewebemarker

Beschränkungen: Nur für Forschungszwecke einsetzbar