Cytokeratin 5 (KRT5) Antikörper

Antigen: Cytokeratin 5 (KRT5)

Synonyme: KRT79, CK5, KRT5, K5, Tfip8, Krt2-5, AW146334, 3300001P10Rik, DDD, EBS2, KRT5A

Klonalität: Monoklonal (XM26)

Wirt: Maus

Reaktivität: Human

Applikation: Immunhistochemie (Gefrierschnitte) (IHC (fro))

Produktnummer: ABIN258650

Produktbeschreibung

Weitere Bezeichnung: Cytokeratin 5

Gen-ID: 3852

Immunogen: BALB/C mice were injected with prokaryotic recombinant protein corresponding to 103amino aced portion of C-terminal region of the human cytokeratin 5 molecule.

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: XM26

Beschreibung: Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinising tissue(ie., skin) and non keratinising cells (ie., mesothelial cells). Although not a traditionalmarker for endothelial cells, cytokeratins have also been found in some microvascularendothelial cells. At least 20 different cytokeratins (CK) in the molecular range of 40 to70 kDa and isoelectric points of 5 to 8.5 can be identified using two dimensional gelelectrophoresis. Biochemically, most members of the CK family fall into one of twoclasses, type I (acidic polypeptides) and type II (basic polypeptides). At least onemember of the acidic family and one member of the basic family is expressed in allepithelial cells. Defects in KRT5 are a cause of epidermolysis bullosa simplex. Alternate Names: anti-58 kDa cytokeratin antibody, anti-CK 5 antibody, anti-CK5 antibody,anti-Cytokeratin5 antibody, anti-DDD antibody, anti-EBS 2 antibody, anti-EBS2antibody, anti-K5 antibody, anti-Keratin 5 (epidermolysis bullosa simplexDowling-Meara/Kobner/Weber-Cockayne types) antibody, anti-Keratin 5 antibody,anti-Keratin Type II Cytoskeletal 5 antibody, anti-Keratin5 antibody, anti-KRT 5 antibody,anti-KRT 5A antibody, anti-KRT5 antibody, anti-KRT5A antibody.

Spezifität: This antibody reacts with cytokeratin 5 intermediate filament protein. Basal cells ofhuman epidermis express acidic cytokeratin 14 and basic cytokeratin 5. Cytokeratin 5 isa 58 kD protein, which is closely related to cytokeratin 6. Cytokeratin 5 and 6 areexpressed in basal cell epithelioma, basal cells of prostate, urothelium, vagina,squamous cell carcinomas of skin, tongue, epiglottis and rectal-anal region. cytokeratin5 can be useful in the distinction of mesotheliomas from most adenocarcinomas. Species Reactivity: Cross reacts with Human. Localization: Cytoplasmic.

Anwendungen

Applikationshinweise: Positive Controls: Skin

Buffer: Tissue culture supernatant. Preservative: Sodium Azide (0.5%).

Lagerung: Store at 4C. Do not freeze.

Forschungsgebiet: Signaltransduktion, Zytoskelett, Zytokeratine, Extrazelluläre Matrix

Beschränkungen: Nur für Forschungszwecke einsetzbar