NADPH Oxidase 4 (NOX4) Antikörper

Antigen: NADPH Oxidase 4 (NOX4)

Synonyme: KOX, KOX-1, RENOX, AI648021, NOX4, nox4, DKFZp469A0217

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Immunhistochemie (Paraffinschnitte) (IHC (p)), Western Blot (WB)

Produktnummer: ABIN258606

Produktbeschreibung

Weitere Bezeichnung: NOX4

Gen-ID: 50507

Immunogen: A synthetic peptide made to a C-terminal region (within residues 500-578) of the humanNOX4 protein sequence. [Swiss-Prot# Q9NPH5].

Beschreibung: Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-typeoxidase, similar to that responsible for the production of large amounts of reactiveoxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity,has been postulated to function in the kidney as an oxygen sensor that regulates thesynthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messengerin the activation of intracellular signaling pathways leading (or contributing) tomitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Datasuggest that NOX4 provides a novel link between the insulin receptor and thegeneration of cellular reactive oxygen species that enhances insulin signal transduction. Alternate Names: anti-NADPH Oxidase 4 antibody, anti-Renal NADPH Oxidase antibody, anti-RENOXantibody, anti-Kidney superoxide-producing NADPH oxidase antibody, anti-KOX-1antibody, anti-EC 1.6.3 antibody. Related Diseases: Atherosclerosis, Insulin resistance, Cancer

Spezifität: Species Reactivity: Reacts with human, mouse, rat, and primate. Localization: Endoplasmic reticulum, endoplasmic reticulum membrane, multi-pass membraneprotein, cell membrane, nucleus (probable).

Anwendungen

Applikationshinweise: Suggested working dilutions: immunohistochemistry 5-10 ug/ml,Western Blot 2 ug/ml

Konzentration: 1 mg/ml

Buffer: Tris-citrate/phosphate, pH 7-8. Preservative: 0.1% sodium azide.

Lagerung: Store at 4C. Do not freeze.

Forschungsgebiet: Kardiovaskuläres System, Artherosklerose, Metabolismus

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Detection of NOX4 in proximal convoluted tubules of human kidney using NB110-55851.

Detection of NOX4 in human kidney lysates uisng ABIN189716 at 0.5 ug/ml. Band observed at 31 kDa may represent reported splice isoform.

Publikationen

Publikationen: Maranchie, Zhan: "Nox4 is critical for hypoxia-inducible factor 2-alpha transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma." in: Cancer research, Vol. 65, Issue 20, pp. 9190-3, 2005 (PubMed).

Basuroy, Bhattacharya, Leffler et al.: "Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells." in: American journal of physiology. Cell physiology, Vol. 296, Issue 3, pp. C422-32, 2009 (PubMed).