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Antikörper
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anti-Transmembrane Emp24-Like Trafficking Protein 10 (Yeast) (TMED10) Antikörper
Transmembrane Emp24-Like Trafficking Protein 10 (Yeast) (TMED10) Antikörper
| Antigen |
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| Synonyme |
TMP21, S31I125, Tmp-21-I, S31III125, P24(DELTA) |
| Klonalität |
Polyklonal |
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Wirt
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Reaktivität
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Applikation
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 Alternativen Immunhistochemie (Paraffinschnitte) (IHC (p)), Western Blot (WB)
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| Produktnummer |
ABIN258482 |
| Menge |
0.1 ml (0.9 mg/ml) (Varianten) |
| Preis |
290,00 € Zzgl. Versandkosten €20,00 und MWSt
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| Lieferung nach |
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| Verfügbarkeit |
Lieferung in 7 bis 10 Werktagen |
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Weitere Bezeichnung
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TMED10 / TMP21
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Gen-ID
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10972, 68581, 84599
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Swiss-Prot
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P49755
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Immunogen
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A synthetic peptide made to an internal sequence of the human TMP21 protein (withinresidues 100-200). [Swiss-Prot# P49755].
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Beschreibung
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TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting andprotein transport. More recent experiments have shown that it is also a component inthe presenilin complex and modulates the gamma-secretase but not theepsilon-secretase cleavage activity of the amyloid precursor protein. The presenilincomplex is composed of the proteins APH1, nicastrin, and PEN2 in addition topresenilin-1. Together, these proteins cleave the amyloid precursor protein at what isknown as the gamma- and epsilon-sites and can lead to the accumulation of the Abetacleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins alsoyielded TMP21 indicating that TMP21 may play a role in the regulation of this complex.Suppression of TMP21 expression by siRNA in transfected cells caused increasedgamma-secretase activity but not epsilon-secretase activity, and increased Abetaproduction, demonstrating that TMP21 can modulate gamma-secretase activity. Alternate Names: anti-Transmembrane emp24 domain-containing protein 10 antibody,anti-Transmembrane protein Tmp21 antibody, anti-21 kDa transmembrane traffickingprotein antibody, anti-p24delta antibody, anti-S31I125 antibody, anti-Tmp-21-I antibody.
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Spezifität
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Species Reactivity: Reacts with human, primate, mouse, rat, cow, hamster, and rabbit. Localization: Type I membrane. Golgi cisternae.
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Applikationshinweise
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Suggested working dilutions: Western Blot 2 ug/ml,Immunohistochemistry-Paraffin
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Konzentration
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0.9 mg/ml
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Buffer
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PBS + 30% glycerol. Preservative: 0.1% sodium azide.
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Lagerung
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Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
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Beschränkungen
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Nur für Forschungszwecke einsetzbar
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Alternativen zu Antigen "Transmembrane Emp24-Like Trafficking Protein 10 (Yeast) (TMED10)", Typ "Antikörper" finden
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Wirte
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Kaninchen (23), Ziege (4)
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Reaktivitäten
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Human (18), Maus (15), Ratte (Rattus) (15), Rind (Kuh) (9), Kaninchen (9), Hamster (8), Affe (8), Xenopus laevis (4), Hund (2), Huhn (1)
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Applikationen
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Western Blot (WB) (24), Immunhistochemie (Paraffinschnitte) (IHC (p)) (12), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (6), Enzyme Immunoassay (EIA) (4), Immunhistochemie (IHC) (2), ELISA (1)
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Konjugate
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Biotin (2), HRP (2)
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Epitope
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C-Term (4), Center (1)
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