Bacillus Anthracis Lethal Factor (LF) Antikörper

Antigen: Bacillus Anthracis Lethal Factor (LF)

Klonalität: Monoklonal (BAL0106)

Wirt: Maus

Applikation: Enzyme Immunoassay (EIA)

Produktnummer: ABIN257993

Produktbeschreibung

Weitere Bezeichnung: Bacillus anthracis lethal factor

Immunogen: Highly purified lethal factor antigen of Bacillus anthracis.

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: BAL0106

Beschreibung: The protease enzyme Lethal Factor (LF) is one of the three proteins (LF, EF & PA)composing the anthrax toxin produced by Bacillus anthracis, a bacteria which can infectmany mammalian species and that may be fatal. LF is not toxic by itself, but whenassociated with Protective Antigen (PA), can then gain entry to cells. Once inside thecell, LF then cleaves the N terminal of most dual specificity mitogen activated proteinkinase kinases (MAPKKs or MAP2Ks) (except for MAP2K5). Cleavage invariably occurswithin the N terminal proline rich region preceding the kinase domain, thus disrupting asequence involved in directing specific protein protein interactions necessary for theassembly of signaling complexes. There may be other cytosolic targets of LF involved incytotoxicity. The proteasome may mediate a toxic process initiated by LF in the cellcytosol involving degradation of unidentified molecules that are essential formacrophage homeostasis. This is an early step in LF intoxication, but it is downstreamof the cleavage by LF of MEK1 or other putative substrates. Alternate Names: anti-Anthrax lethal factor antibody, anti-Anthrax lethal toxin endopeptidase componentantibody, anti-Anthrax LF antibody, anti-B.anthracis lethal factor antibody, anti-bacillusanthracis lethal factor antibody, anti-Lef antibody, anti-LF antibody.

Spezifität: Lethal factor antigen of Bacillus anthracis. Species Reactivity: Bacteria. Not tested in other species.

Anwendungen

Applikationshinweise: Recommended in ELISA as the coating antigbody with ab8242 as the conjatingantibody.

Buffer: PBS. Preservative: 0.1% sodium azide.

Lagerung: Store at 4C. Do not freeze.

Forschungsgebiet: Bakterien, Gram-positive Bakterien, Toxine, Virologie

Beschränkungen: Nur für Forschungszwecke einsetzbar