X-Box Binding Protein 1 (XBP1) Antikörper

Antigen: X-Box Binding Protein 1 (XBP1)

Synonyme: XBP2, TREB5, XBP-1, TREB-5, D11Ertd39e, cb918, treb5, trebf, xbp1a, xbp1b, id:ibd1195, wu:fb02h05, wu:fb63f10, HTF, xbp1, MGC53678, MGC130816, xbp2, xXBP1, MGC76163, XBP1, XBPP1, MGC127699

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Ratte (Rattus)

Applikation: Immunhistochemie (Gefrierschnitte) (IHC (fro)), Western Blot (WB)

Produktnummer: ABIN256411

Produktbeschreibung

Weitere Bezeichnung: XBP1 / TREB5

Gen-ID: 7494, 289754

Immunogen: Peptide-KLH (DTFANELFPQLISV).

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Xbp-1 (X-box binding protein 1) is a ubiquitously expressed 29 kD member of theCREB/ATF transcription factor family, and a mammalian homologue of the yeasttranscription factor Hac1. Xbp-1 regulates MHC class II genes by binding to the X-boxpromoter motif and can also bind to the enhancer in T cell leukemia virus type Ipromoter to increase viral protein expression by binding the viral transactivator. Thistranscription factor is essential for hepatocyte differentiation and can be upregulated byER stress, IL-6, and IL-4. The PAX5 transcription factor downregulates Xbp-1, downregulation has been shown to correlate with tumor progression in prostate cancer.The Poly6195 antibody recognizes the C-terminal region of human and rat Xbp-1 andhas been shown to be useful for Western blotting. Alternate Names: anti-X-box binding protein 1 antibody, anti-XBP1 antibody.

Spezifität: Species Reactivity: Human, Rat, and weak reactive with Mouse, recognizes the 54 kD form.

Anwendungen

Applikationshinweise: Positive Controls: Ubiquitously expressed

Buffer: This antibody is provided in phosphate-buffered solution, pH 7.2 with 50% glycerol. Preservative: 0.09% sodium azide.

Lagerung: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

HepG2 nuclear extract was resolved by electrophoresis, transferred to nitrocellulose, and probed with rabbit anti-Xbp-1 antibody. Proteins were visualized using a donkey anti-rabbit secondary conjugated to HRP and a chemiluminescence detection system. This antibody recognizes the 54 kD splice variant of Xbp-1.