T Cell Receptor (TCR) alpha/beta (alpha chain) (alpha chain) Antikörper

Antigen: T Cell Receptor (TCR) alpha/beta (alpha chain)

Epitope: alpha chain

Klonalität: Monoklonal (3A8)

Wirt: Maus

Reaktivität: Human

Applikation: Immunhistochemie (Gefrierschnitte) (IHC (fro)), Immunpräzipitation (IP)

Produktnummer: ABIN256182

Produktbeschreibung

Isotyp: IgG2a  (Passende Sekundärantikörper)

Klon: 3A8

Beschreibung: The receptors on T cells consist of immunoglobulin like integral membrane glycoproteinscontaining 2 polypeptide subunits, alpha and beta, of similar molecular weight, 40 to 55kD in the human. Like the immunoglobulins of the B cells, each T cell receptor subunithas, external to the cell membrane, an N terminal variable domain and a C terminalconstant domain. T cell receptors recognise foreign antigens which have beenprocessed as small peptides and bound to major histocompatibility complex moleculesat the surface of antigen presenting cells. Each T cell receptor is a dimer consisting ofone alpha and one beta chain or one delta and one gamma chain. In a single cell, the Tcell receptor loci are rearranged and expressed in the order delta, gamma, beta, andalpha. If both delta and gamma rearrangements produce functional chains, the cellexpresses delta and gamma. If not, the cell proceeds to rearrange the beta and alphaloci.

Spezifität: Reacts with the alpha chain constant region found on all alpha beta TCR bearingT-lymphocytes. It reacts with 92-98% of all CD3 + peripheral blood lymphocytes. Species Reactivity: Reacts with Human. Does not react with Mouse or Rat.

Anwendungen

Konzentration: 0.1 mg/ml

Buffer: PBS, 0.5% Bovine Serum Albumin. Preservative: 0.09% Sodium Azide.

Lagerung: Store at 4C. Do not freeze.

Forschungsgebiet: Immunologie, Rezeptoren

Beschränkungen: Nur für Forschungszwecke einsetzbar