Carbohydrate Antigen 19-9 (CA19-9) Antikörper

Antigen: Carbohydrate Antigen 19-9 (CA19-9)

Klonalität: Monoklonal (1116-NS-19-9)

Wirt: Maus

Reaktivität: Human

Applikation: Immunhistochemie (Gefrierschnitte) (IHC (fro)), Immunhistochemie (Paraffinschnitte) (IHC (p))

Produktnummer: ABIN256048

Produktbeschreibung

Weitere Bezeichnung: CA 19-9

Immunogen: SW1116 human colorectal cancer cells.

Format: Serum

Isotyp: IgG1

Klon: 1116-NS-19-9

Beschreibung: Mucin glucoprotein is a sialyl Lewisa structure which is synthesized from type 1 bloodgroup precursor chains and is present in individuals expressing the Lewisa and/orLewisb blood group antigens. In normal tissues, sialyl Lewisa antigen is present inductal epithelium of the breast, kidney, salivary gland, and sweat glands. Its expressionis greatly enhanced in serum as well as in the majority of tumor cells in gastrointestinal(GI) carcinomas. Alternate Names: anti-Sialyl Lewis (a) antibody, anti-Sialyl Lewis(a) antibody, anti-Sialyl Lewisa antibody.

Spezifität: This antibody is a carbohydrate antigenic determinant identified as a sialylatedlacto-N-fucopentose II, an oligosaccharide biochemically related to the Lewis A bloodgroup antigen. In malignant tissues positive staining of tumor cells is observed in mostadenocarcinomas of the pancreas and stomach, and in a large proportion of colon andgall bladder tumors. The antigen is also expressed in approximately half of primary andmetastatic ovarian tumors. In normal tissues positive staining is also observed incolumnor epithelium of the pancreas stomach, liver, gall bladder and in bronchial glandsof the lung. Species Reactivity: Reacts with Human.

Anwendungen

Applikationshinweise: Suggested working dilutions: Immunohistochemistry-Paraffin 1:10 - 1:40,Immunohistochemistry-Frozen 1:10 - 1:40. Positive Controls: Adenocarcinoma of colon

Buffer: PBS, 1%Bovine Serum Albumin. Preservative: 0.09% Sodium Azide.

Lagerung: Store at 4C. Do not freeze.

Forschungsgebiet: Krebs, Zell-/Gewebemarker, Blutbestandteile

Beschränkungen: Nur für Forschungszwecke einsetzbar