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CILP Antikörper (AA 1051-1184) (HRP)

CILP Reaktivität: Human, Ratte WB, ELISA, IHC (fro), IHC (p) Wirt: Kaninchen Polyclonal HRP
Produktnummer ABIN2559701
  • Target Alle CILP Antikörper anzeigen
    CILP (Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase (CILP))
    Bindungsspezifität
    • 15
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1051-1184
    Reaktivität
    • 25
    • 17
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Ratte
    Wirt
    • 19
    • 4
    • 2
    • 2
    Kaninchen
    Klonalität
    • 24
    • 3
    Polyklonal
    Konjugat
    • 12
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CILP Antikörper ist konjugiert mit HRP
    Applikation
    • 24
    • 14
    • 13
    • 13
    • 8
    • 3
    • 2
    • 2
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    The immunogen falls within the Cartilage intermediate layer protein 1 C2 region.
    Kreuzreaktivität
    Human, Ratte
    Homologie
    Mouse,Cow,Sheep,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human CILP
    Isotyp
    IgG
    Top Product
    Discover our top product CILP Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Handhabung
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    CILP (Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase (CILP))
    Andere Bezeichnung
    CILP (CILP Produkte)
    Synonyme
    CILP-1 antikoerper, HsT18872 antikoerper, 9830114D16 antikoerper, C130036G17Rik antikoerper, NTPPH antikoerper, CILP antikoerper, im:7137994 antikoerper, cartilage intermediate layer protein antikoerper, cartilage intermediate layer protein, nucleotide pyrophosphohydrolase antikoerper, cartilage intermediate layer protein 1 antikoerper, CILP antikoerper, Cilp antikoerper, cilp antikoerper, LOC100336614 antikoerper
    Hintergrund

    Synonyms: CILP-1, HsT18872, Cartilage intermediate layer protein 1, Cartilage intermediate-layer protein, CILP, UNQ602/PRO1188

    Background: Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.

    Gen-ID
    8483
    UniProt
    O75339
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