T Cell Receptor (TCR) Vb 10b Antikörper

Antigen: T Cell Receptor (TCR) Vb 10b

Klonalität: Monoklonal (KT10b)

Wirt: Ratte

Reaktivität: Maus

Applikation: Immunhistochemie (Gefrierschnitte) (IHC (fro)), Durchflusszytometrie (FACS)

Produktnummer: ABIN255953

Produktbeschreibung

Immunogen: V beta10b T cell receptor.

Format: Supernatant

Isotyp: IgG2b  (Passende Sekundärantikörper)

Klon: KT10b

Beschreibung: The receptors on T cells consist of immunoglobulin like integral membrane glycoproteinscontaining 2 polypeptide subunits, alpha and beta, of similar molecular weight, 40 to 55kD in the human. Like the immunoglobulins of the B cells, each T cell receptor subunithas, external to the cell membrane, an N terminal variable domain and a C terminalconstant domain. T cell receptors recognize foreign antigens which have beenprocessed as small peptides and bound to major histocompatibility complex moleculesat the surface of antigen presenting cells. Each T cell receptor is a dimer consisting ofone alpha and one beta chain or one delta and one gamma chain. In a single cell, the Tcell receptor loci are rearranged and expressed in the order delta, gamma, beta, andalpha. If both delta and gamma rearrangements produce functional chains, the cellexpresses delta and gamma. If not, the cell proceeds to rearrange the beta and alphaloci.

Spezifität: Reacts with mouse T cells expressing T cell receptor V beta 10b. Species Reactivity: Reacts with Mouse.

Anwendungen

Applikationshinweise: Suggested working dilutions: flow cytometry / FACS analysis 1:2 - 1:4,Immunohistochemistry-Frozen 1:2 - 1:4

Buffer: 0.2M Tris/HCl pH7.4 and 5-10% fetal calf serum. Preservative: 0.09% Sodium Azide.

Lagerung: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Forschungsgebiet: Immunologie, Rezeptoren, Signaltransduktion

Beschränkungen: Nur für Forschungszwecke einsetzbar