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Antikörper
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anti-Complement Factor I (CFI) Antikörper
Complement Factor I (CFI) Antikörper
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| Synonyme |
FI, IF, KAF, AHUS3, C3BINA, C3b-INA, cfi, MGC53615, Cfi, factor I, CFI, MGC128240, DKFZp470D0233 |
| Klonalität |
Monoklonal (3R-8) |
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Wirt
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Reaktivität
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Applikation
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 Alternativen Immunhistochemie (Gefrierschnitte) (IHC (fro)), Enzyme Immunoassay (EIA), Funktionale Studien (Func), Western Blot (WB)
Western Blot (WB) (15), Enzyme Immunoassay (EIA) (10), Immunpräzipitation (IP) (6), ELISA (Detektionsantikörper) (3), Durchflusszytometrie (FACS) (3), Immunhistochemie (Paraffinschnitte) (IHC (p)) (3), Radioimmunoassay (RIA) (3), ELISA (2), Immunhistochemie (IHC) (2), Funktionale Studien (Func) (1), Immunodiffusion (ID) (1), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (1)
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| Produktnummer |
ABIN255828 |
| Menge |
0.1 mg (1.0mg/ml) |
| Preis |
560,00 € Zzgl. Versandkosten €20,00 und MWSt
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| Lieferung nach |
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| Verfügbarkeit |
Lieferung in 7 bis 10 Werktagen |
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Weitere Bezeichnung
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Complement factor I
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Gen-ID
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3426
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Immunogen
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native human factor I from serum.
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Isotyp
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IgG1 (Passende Sekundärantikörper)
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Klon
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3R-8
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Beschreibung
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Factor I is a plasma protein of molecular weight 88 kDa, consisting of two disulphidelinked chains of 50 and 38 kDa. Factor I is a serine protease with a high degree ofspecificity for C3b and C4b. It has a requirement for protein cofactors for cleavage ofthese complement proteins, Factor H, CR1 or MCP are required for C3b cleavage andC4bp or CR1 for C4b cleavage. Alternate Names: anti-C3b INA antibody, anti-C3b inactivator antibody, anti-C3B/C4B inactivator antibody,anti-CFI antibody, anti-Complement factor I antibody, anti-F1 antibody, anti-factor Iantibody, anti-FactorI antibody, anti-FI antibody, anti-I factor antibody, anti-IF antibody,anti-KAF antibody, anti-Konglutinogen activating factor antibody, anti-Light chain offactor I antibody.
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Spezifität
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Recognizes complement factor I, a member of the peptidase S1 family present in theblood plasma. Factor I is an 88 kDa protein consisting of one polypeptide chain of 35.4kDa and one of 27.6 kDa. Factor I is a serine protease which inactivates complementcomponents C3b and C4b. C3b cleavage requires the presence of cofactorscomplement component (3b/4b) receptor 1 (CR1), membrane cofactor protein or factorH, while C4b cleavage requires complement component 4 binding protein or CR1.Factor I has no natural inhibitors.Dysfunctional factor I can lead to uncontrolled activation of the alternative complementpathway causing in systemic depletion of C3 and lower levels of factors B and H,resulting in recurrent pyogenic infections. Defects in CFI are also associated withhaemolytic uraemic syndrome. Blocks function of complement factor I. Removal ofSodium Azide is recommended prior to use in functional assays. Species Reactivity: Reacts with Human.
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Applikationshinweise
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Suggested working dilutions: ELISA 1:3000 - 1:4000, Positive Controls: Kidney from post streptoccal glomerulonephritis patients
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Konzentration
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1.0mg/ml
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Buffer
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Borate buffered saline pH8.4
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Lagerung
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Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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Forschungsgebiet
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Gerinnung
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Beschränkungen
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Nur für Forschungszwecke einsetzbar
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Alternativen zu Antigen "Complement Factor I (CFI)", Typ "Antikörper" finden
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Wirte
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Maus (14), Kaninchen (3), Schaf (2)
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Reaktivitäten
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Human (18)
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Applikationen
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Western Blot (WB) (15), Enzyme Immunoassay (EIA) (10), Immunpräzipitation (IP) (6), ELISA (Detektionsantikörper) (3), Durchflusszytometrie (FACS) (3), Immunhistochemie (Paraffinschnitte) (IHC (p)) (3), Radioimmunoassay (RIA) (3), ELISA (2), Immunhistochemie (IHC) (2), Funktionale Studien (Func) (1), Immunodiffusion (ID) (1), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (1)
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