T Cell Receptor (TCR) Vb 8.5 Antikörper

Antigen: T Cell Receptor (TCR) Vb 8.5

Klonalität: Monoklonal (B73)

Wirt: Maus

Reaktivität: Ratte (Rattus)

Applikation: Durchflusszytometrie (FACS)

Produktnummer: ABIN255352

Produktbeschreibung

Immunogen: T cell clone expressing the TCR Vb8.5 gene product.

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: B73

Beschreibung: The receptors on T cells consist of immunoglobulin like integral membrane glycoproteinscontaining 2 polypeptide subunits, alpha and beta, of similar molecular weight, 40 to 55kD in the human. Like the immunoglobulins of the B cells, each T cell receptor subunithas, external to the cell membrane, an N terminal variable domain and a C terminalconstant domain.T cell receptors recognise foreign antigens which have been processed as smallpeptides and bound to major histocompatibility complex molecules at the surface ofantigen presenting cells. Each T cell receptor is a dimer consisting of one alpha and onebeta chain or one delta and one gamma chain. In a single cell, the T cell receptor lociare rearranged and expressed in the order delta, gamma, beta, and alpha. If both deltaand gamma rearrangements produce functional chains, the cell expresses delta andgamma. If not, the cell proceeds to rearrange the beta and alpha loci.

Spezifität: ABIN255352 is specific for the T-cell receptor V beta 8.5 gene product.4% ofunseparated LEW rat lymph node cells label with this antibody. Reactivity is restricted toab T cells of which 6.5% were stained (1). Species Reactivity: Rat. Not yet tested in other species. Localization: Plasma membrane.

Anwendungen

Applikationshinweise: Suggested working dilutions: flow cytometry / FACS analysis 1/50 - 1/100

Konzentration: 1.0 mg/ml

Buffer: Phosphate buffered saline pH7.4. Preservative: 0.09% Sodium Azide (NaN3).

Lagerung: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Forschungsgebiet: Immunologie, Rezeptoren, Signaltransduktion

Beschränkungen: Nur für Forschungszwecke einsetzbar