T Cell Receptor (TCR) Vb 4 Antikörper

Antigen: T Cell Receptor (TCR) Vb 4

Klonalität: Monoklonal (KT4)

Wirt: Ratte

Reaktivität: Maus

Applikation: Durchflusszytometrie (FACS)

Produktnummer: ABIN255348

Produktbeschreibung

Immunogen: T cell clone 13.

Isotyp: IgG2b  (Passende Sekundärantikörper)

Klon: KT4

Beschreibung: The receptors on T cells consist of immunoglobulin like integral membrane glycoproteinscontaining 2 polypeptide subunits, alpha and beta, of similar molecular weight, 40 to 55kD in the human. Like the immunoglobulins of the B cells, each T cell receptor subunithas, external to the cell membrane, an N terminal variable domain and a C terminalconstant domain.T cell receptors recognise foreign antigens which have been processed as smallpeptides and bound to major histocompatibility complex molecules at the surface ofantigen presenting cells. Each T cell receptor is a dimer consisting of one alpha and onebeta chain or one delta and one gamma chain. In a single cell, the T cell receptor lociare rearranged and expressed in the order delta, gamma, beta, and alpha. If both deltaand gamma rearrangements produce functional chains, the cell expresses delta andgamma. If not, the cell proceeds to rearrange the beta and alpha loci.

Spezifität: ABIN255348 recognises the V beta 4 chain of the murine T cell receptor. Species Reactivity: Mouse. Not yet tested in other species. Localization: Plasma membrane.

Anwendungen

Applikationshinweise: Suggested working dilutions: flow cytometry / FACS analysis 1/100 - 1/200

Konzentration: 1.0 mg/ml

Buffer: Phosphate buffered saline pH 7.4. Preservative: 0.09% Sodium Azide (NaN3).

Lagerung: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Forschungsgebiet: Immunologie, Rezeptoren, Signaltransduktion

Beschränkungen: Nur für Forschungszwecke einsetzbar