CD247 Molecule (CD247) Antikörper (PE)

Antigen: CD247 Molecule (CD247)

Synonyme: T3Z, CD3H, CD3Q, CD3Z, TCRZ, CD3-ZETA, Cd3, T3z, Cd3h, Cd3z, TCRk, Tcrz, CD3-eta, CD3zeta, AW552088, CD3-zeta, 4930549J05Rik, A430104F18Rik, CD247, im:7156386, LOC100136514, LOC100136549, LOC100305023

Klonalität: Monoklonal (R73)

Wirt: Maus

Reaktivität: Ratte (Rattus)

Konjugat: PE

Applikation: Durchflusszytometrie (FACS)

Produktnummer: ABIN255340

Produktbeschreibung

Weitere Bezeichnung: T Cell Receptor (TCR) alpha/beta

Immunogen: Rat T Blasts and Erythrocytes.

Isotyp: IgG1

Klon: R73

Beschreibung: The receptors on T cells consist of immunoglobulin like integral membrane glycoproteinscontaining 2 polypeptide subunits, alpha and beta, of similar molecular weight, 40 to 55kD in the human. Like the immunoglobulins of the B cells, each T cell receptor subunithas, external to the cell membrane, an N terminal variable domain and a C terminalconstant domain. T cell receptors recognise foreign antigens which have beenprocessed as small peptides and bound to major histocompatibility complex moleculesat the surface of antigen presenting cells. Each T cell receptor is a dimer consisting ofone alpha and one beta chain or one delta and one gamma chain. In a single cell, the Tcell receptor loci are rearranged and expressed in the order delta, gamma, beta, andalpha. If both delta and gamma rearrangements produce functional chains, the cellexpresses delta and gamma. If not, the cell proceeds to rearrange the beta and alphaloci. Alternate Names: anti-FLJ22602 antibody, anti-MGC117436 antibody, anti-MGC22624 antibody,anti-MGC23964 antibody, anti-MGC71411 antibody, anti-T cell antigen receptor alphapolypeptide antibody, anti-T cell antigen receptor beta polypeptide antibody, anti-T cellreceptor alpha antibody, anti-T cell receptor alpha chain antibody, anti-T cell receptoralpha chain V region CTL L17 antibody, anti-T cell receptor alpha locus antibody, anti-Tcell receptor beta chain antibody, anti-T cell receptor beta chain V region CTL L17antibody, anti-T cell receptor beta cluster antibody, anti-T cell receptor beta locusantibody, anti-TCRA antibody, anti-TCRB antibody, anti-TCRD antibody, anti-TRAantibody, anti-TRA@ antibody, anti-TRB antibody, anti-TRB@ antibody, anti-TRDD 3antibody, anti-TRDD3 antibody.

Spezifität: Detects a T cell specific molecule consisting of two disulphide-linked subunits of 40 and46 kD molecular weight respectively on 97% of peripheral rat T cells as defined by theOX-52 marker. R73 is mitogenic for unseparated spleen cells and for purified T cells. Inthe rat thymus, mature medullary cells express the R73 determinant at the same levelas peripheral T cells, whereas 94% of CD4 - CD8 - thymocytes are R73 negative. It ismost likely directed at a constant determinant of the rat a/b heterodimeric T cell antigenreceptor. Species Reactivity: Cross reacts with Monkey, Cynomolgus monkey and Rat.

Anwendungen

Buffer: Phosphate buffered saline pH7.2 lyophilised. Preservative: 0.09% Sodium Azide.

Lagerung: Store at 4C. Do not freeze.

Forschungsgebiet: Immunologie, Rezeptoren, Signaltransduktion

Beschränkungen: Nur für Forschungszwecke einsetzbar