Bone Morphogenetic Protein 4 (BMP4) Antikörper

Antigen: Bone Morphogenetic Protein 4 (BMP4)

Synonyme: ZYME, BMP2B, OFC11, BMP2B1, MCOPS6, Bmp-4, Bmp2b, Bmp2b1, Bmp2b-1, BOMPR4A, bmp-4, zbmp-4, MGC100779, zgc:100779, BMP4, BMP-4, xbmp4, XBMP-4, Bmp4, MGC127497, zyme, bmp2b, bmp2b1, bmp4

Klonalität: Monoklonal (3H2)

Wirt: Maus

Reaktivität: Human

Applikation: Enzyme Immunoassay (EIA), Western Blot (WB)

Produktnummer: ABIN254272

Produktbeschreibung

Weitere Bezeichnung: BMP4

Gen-ID: 652

Immunogen: Recombinant Human BMP-4 expressed in E.coli.

Isotyp: IgG2b  (Passende Sekundärantikörper)

Klon: 3H2

Beschreibung: Bone Morphogenetic Proteins (BMPs) are members of the TGF beta superfamily ofcytokines that affect bone and cartilage formation. Similar to other TGF beta familyproteins, BMPs are highly conserved across animal species. Mature BMPs are 30-38kDa proteins that assume a TGF beta like cysteine knot configuration. Unlike TGF beta,BMPs do not form latent complexes with their propeptide counterparts. Most BMPs arehomodimers, but bioactive natural heterodimers have been reported. Recently it wasfound that lovostatin, widely used for lowering cholesterol, also increases boneformation by turning on a gene (bmp2) that promotes local bone formation. BMPs createan environment conducive for bone marrow development by stimulating the productionof specific bone matrix proteins and altering stromal cell and osteoclast proliferation. Inaddition to stimulating ectopic bone and cartilage development, BMPs may be animportant factor in the development of the viscera, with roles in cell proliferation,apoptosis, differentiation, and morphogenesis. BMPs also appear to be responsible fornormal dorsal/ventral patterning. BMPs are found in tissues that induce bone orcartilage growth, such as demineralized bone and urinary epithelium. Cellular responsesto BMP5 are mediated by the formation of hetero-oligomeric complexes of type I andtype II serine/threonine kinase receptors which play significant roles in BMP binding andsignaling. One BMP type II receptor and two BMP type I receptors have been identified. Alternate Names: Anti-BMP 2B antibody, Anti-BMP 4 antibody, Anti-BMP2B antibody, Anti-BMP2B1antibody, Anti-Bone morphogenetic protein 4 antibody, Anti-DVR4 antibody, Anti-ZYMEantibody.

Spezifität: ABIN254272 recognizes the disulphide-linked homodimeric cysteine knot proteinknown as human Bone Morphogenetic Protein 4 (BMP-4/BMP-2b), full-length 408aa.BMP-4 is a member of the Transforming Growth Factor beta (TGF-B) superfamily andone of a growing number of osteogenic proteins shown to induce bone and cartilageformation and to play an important role in developmental processes, including cellproliferation, differentiation, apoptosis and morphogenesis.BMPs act through binding with a receptor complex consisting of type I and type IIserine/threonine kinases, resulting ultimately in the activation of the Smad protein andmitogen-activated protein kinase (MAPK) signaling pathways. Several antagonistproteins, including, noggin, chordin, gremlin and follistatin, are responsible formodulating the signaling effects of BMPs, through the binding and blocking of receptorligands, thereby preventing activation.Research studies have verified the particular importance of BMP-4 inepithelial-mesenchymal interactions, including its vital role in the early stages of toothmorphogenesis (3), the interaction between BMP-4 and its antagonist noggin in hairfollicles (4) and the effects of BMP-4 expression/signaling in organs, including the lungs(5) and eyes (6). Species Reactivity: Human. Not yet tested in other species. Localization: Secreted, extracellular matrix.

Anwendungen

Konzentration: 1.0 mg/ml

Buffer: Phosphate buffered saline, pH7.2. Preservative: 0.09% Sodium Azide.

Lagerung: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Forschungsgebiet: Organogenese, Wachstumsfaktoren, Angiogenese, Signaltransduktion

Beschränkungen: Nur für Forschungszwecke einsetzbar