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Antikörper
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anti-4-Hydroxynonenal (HNE) Antikörper
4-Hydroxynonenal (HNE) Antikörper
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| Klonalität |
Polyklonal |
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Wirt
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Reaktivität
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Applikation
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| Produktnummer |
ABIN254254 |
| Menge |
0.1 ml |
| Preis |
430,00 € Zzgl. Versandkosten €20,00 und MWSt
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| Lieferung nach |
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| Verfügbarkeit |
Lieferung in 7 bis 10 Werktagen |
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Weitere Bezeichnung
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4-Hydroxy-2-Nonenal (HNE)
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Immunogen
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4-hydroxynonenal conjugate.
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Isotyp
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IgG (Passende Sekundärantikörper)
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Beschreibung
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Alternate Names: Anti-4 HNE antibody.
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Spezifität
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ABIN254254 recognises 4-hydroxynonenal (HNE). A 65 kDa, highly reactive aldehydereleased upon oxidation of omega-6-insaturated fatty acids, often by free radicals. HNEacts to spread and increase the initial effects of free radical events. It binds nucleicacids, phospholipids and sulfhydryl, histidine and lysine groups. These conjugatescause the cytotoxic effects (including cell death) that occur during oxidative stress dueto hydrogen peroxide, superoxide, UV, heat and oxidant chemicals. HNE plays a role inthe pathogenesis of diseases, stimulating fibrogenesis and inflammation. It is thought toact as a sensor of external stimuli, inducing the stress response by modulatingmembrane receptors such as Epidermal growth factor receptor or Fas.It is thought that constitutive levels of HNE may be needed for normal cell functions asdecreased HNE levels are associated with cell proliferation and increased HNE levelswith elevated apoptosis. Species Reactivity: Chemical. Localization: Cytoplasmic.
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Buffer
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Preservative: Sodium Azide.
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Lagerung
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Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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Beschränkungen
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Nur für Forschungszwecke einsetzbar
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Alternativen zu Antigen "4-Hydroxynonenal (HNE)", Typ "Antikörper" finden
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Wirte
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Kaninchen (21), Ziege (11), Maus (2)
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Reaktivitäten
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Human (20), Maus (17), Ratte (Rattus) (16), Rind (Kuh) (6), Hund (6), Pferd (3), Schwein (3), Kaninchen (2), Huhn (1)
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Applikationen
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Durchflusszytometrie (FACS) (17), Immunfluoreszenz (IF) (16), Western Blot (WB) (9), ELISA (8), Enzyme Immunoassay (EIA) (6), Immunhistochemie (Paraffinschnitte) (IHC (p)) (4), Immunoelectron Microscopy (IEM) (1), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)) (1), Immunpräzipitation (IP) (1)
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Konjugate
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Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
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Alternativen 
