Huntingtin (HTT) Antikörper

Antigen: Huntingtin (HTT)

Synonyme: HD, IT15, Hd, Hdh, AI256365, C430023I11Rik, hd, ZHD, HTT, HsapHD, dhtt, DmelCG9995, CG9995, Htt, HDH, SLC6A4, it15, MGC79590, htt, LOC100216476

Klonalität: Monoklonal (1A771)

Wirt: Maus

Reaktivität: Human, Maus

Applikation: Western Blot (WB)

Produktnummer: ABIN252646

Produktbeschreibung

Weitere Bezeichnung: Huntingtin

Gen-ID: 3064, 15194

Immunogen: The antibody was raised against a fusion protein containing 62 glutamine amino acidrepeat.

Isotyp: IgG  (Passende Sekundärantikörper)

Klon: 1A771

Beschreibung: Huntington's disease (HD) is a neurodegenerative disorder caused by an expandingpolyglutamine repeat in the huntingtin gene. HD is a mid-life onset autosomal dominantneurodegenerative disease that is characterized by psychiatric disorders, dementia, andinvoluntary movements (chorea), leading to death in 10-20 years. The HD gene productis widely expressed in human tissues, with the highest level of expression in the brain.The huntington gene product is expressed at similar levels in patients and controls,which suggests that the expansion of the polyglutamine repeat induces a toxic gain offunction perhaps through interactions with other cellular proteins. Using yeast two-hybridsystem Li et al., have identified a protein, HAP1 (huntington associated protein 1), thatassociates with huntingtin protein. The in vitro data suggest that the associationbetween HAP1 and huntington is enhanced by increasing length of glutamine repeat. Alternate Names: anti-HD antibody, anti-HD protein antibody, anti-HDH antibody, anti-HTT antibody,anti-HUNTINGTON CHOREA antibody, anti-Huntington disease protein antibody,anti-Huntington',s disease protein homolog antibody, anti-IT 15 antibody, anti-IT15antibody, anti-ZHD antibody.

Spezifität: Species Reactivity: Human, Mouse Not yet tested in other species.

Anwendungen

Applikationshinweise: Suggested working dilutions: Western Blot 1 ug/ml. Positive Controls: Lymphoblast cell line extracts

Buffer: PBS. Preservative: 0.05 % Sodium Azide.

Lagerung: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.

Forschungsgebiet: Neurologie, Virologie

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Western blot analysis of Huntington Disease protein in different lymphoblast cell line extracts (Lanes 1-4) (CAG repeats ~65 and ~20) using anti-huntingtin mAb (ABIN252646) (Panel A) and an antibody from another source (Panel B).