X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3) Antikörper

Antigen: X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3)

Synonyme: AI182522, AW537713, 4432412E01Rik, MGC69118, im:7142103, zgc:101608, si:dkey-11b8.1, xrcc3, XRCC3, MGC142843

Klonalität: Monoklonal (10F1-6)

Wirt: Maus

Reaktivität: Human

Applikation: Western Blot (WB)

Produktnummer: ABIN250516

Produktbeschreibung

Weitere Bezeichnung: XRCC3

Gen-ID: 7517

Immunogen: His-tagged human XRCC3, over-expressed in E. coli.

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: 10F1-6

Beschreibung: Five human RAD51 homologs have been identified: XRCC2, XRCC3, RAD51B,RAD51C, and RAD51D. Each of these homologs interacts with one or more of theothers, with all of the proteins involved in one complex or multiple smaller complexes.XRCC3 (x-ray cross complementing) was first identified as a human genecomplementing the DNA damage sensitivity, chromosonal instability and impairedgrowth of the mutant hamster cell line irs1SF. This fact coupled with XRCC3 being amember of the RAD51 gene family have implied a role in the repair of DNA damage byhomologous recombination. Alternate Names: anti-DNA repair protein XRCC3 antibody, anti-X ray repair complementing defectiverepair in Chinese hamster cells 3 antibody, anti-X ray repair cross complementingprotein 3 antibody.

Spezifität: This antibody is specific for XRCC3. Species Reactivity: Human XRCC3. Does not work in mouse. Other species not tested. ABIN151307 doesnot cross-react with Rad51B, Rad51C, Rad51D, Rad51, or XRCC2 in Western analysis. Localization: Nuclear.

Anwendungen

Applikationshinweise: Suggested working dilutions: Western Blot 1:1000

Konzentration: 1.3 mg/ml

Buffer: Preservative: 0.1% sodium azide.

Lagerung: Store at 4C. Do not freeze.

Forschungsgebiet: Chromatin und nukleäre Signaltransduktion, Chromatin-Bindungsproteine, DNS/RNS

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Western Blot: XRCC3 Antibody (10F1/6) [ABIN151307SS] - XRCC3 detected in HEK293 lysates using a 1:1,000 dilution of Protein A purified ABIN151307. Photo courtesy of B.T. Bennett & K. Knight of University of Massachusetts Medical School

Publikationen

Publikationen: Forget, Bennett, Knight: "Xrcc3 is recruited to DNA double strand breaks early and independent of Rad51." in: Journal of cellular biochemistry, Vol. 93, Issue 3, pp. 429-36, 2004 (PubMed).

Fan, Kumaravel, Jalali et al.: "Defective DNA strand break repair after DNA damage in prostate cancer cells: implications for genetic instability and prostate cancer progression." in: Cancer research, Vol. 64, Issue 23, pp. 8526-33, 2004 (PubMed).