RAD51-Like Protein 3 (RAD51L3) Antikörper

Antigen: RAD51-Like Protein 3 (RAD51L3)

Synonyme: Trad, R51H3, HsTRAD, RAD51D

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Western Blot (WB)

Produktnummer: ABIN250467

Produktbeschreibung

Weitere Bezeichnung: RAD51L3

Gen-ID: 5892

Immunogen: A peptide from human RAD51D (homologue 4).

Beschreibung: Five human RAD51 homologues have been identified: XRCC2, XRCC3, RAD51B,RAD51C, and RAD51D. Each of these homologues interacts with one or more of theother four, with all of the proteins involved in one complex or multiple smallercomplexes. RAD51D interacts with XRCC2 and RAD51C. RAD51D',s expressionpattern and sequence similarity to other RAD51 family members most likely makes itpart of a complex of proteins required for DNA repair and meiotic recombination. Alternate Names: anti-RAD51L3 antibody, anti-RAD51-like 3 (S. cerevisiae) antibody, anti-TRAD antibody,anti-R51H3 antibody, anti-HsTRAD antibody, anti-RAD51D antibody, anti-recombinationrepair protein antibody, anti-DNA repair protein RAD51 homolog 4 antibody.

Spezifität: This antibody is specific for hRAD51D. There is no cross-reactivity observed withXRCC2, XRCC3, RAD51, RAD51B, or RAD51C. Species Reactivity: ABIN151188 reacts with human RAD51D. It does not work in mouse. Other specieshave not been tested.

Anwendungen

Applikationshinweise: Suggested working dilutions: Western Blot 1:1,000

Konzentration: 1.9 mg/ml

Buffer: PBS. Preservative: 0.05% sodium azide.

Lagerung: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Western blot detection of Rad51D (35 kDa) from Hela S3 cell extract using ABIN151188.

Publikationen

Publikationen: Schild, Lio, Collins et al.: "Evidence for simultaneous protein interactions between human Rad51 paralogs." in: The Journal of biological chemistry, Vol. 275, Issue 22, pp. 16443-9, 2000 (PubMed).

Hinz, Tebbs, Wilson et al.: "Repression of mutagenesis by Rad51D-mediated homologous recombination." in: Nucleic acids research, Vol. 34, Issue 5, pp. 1358-68, 2006 (PubMed).

Wiese, Hinz, Tebbs et al.: "Disparate requirements for the Walker A and B ATPase motifs of human RAD51D in homologous recombination." in: Nucleic acids research, Vol. 34, Issue 9, pp. 2833-43, 2006 (PubMed).

Chattopadhyay, Das, Maiti et al.: "Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1." in: Molecular and cellular biology, Vol. 28, Issue 23, pp. 7066-80, 2008 (PubMed).

Shammas, Shmookler Reis, Koley et al.: "Dysfunctional homologous recombination mediates genomic instability and progression in myeloma." in: Blood, Vol. 113, Issue 10, pp. 2290-7, 2009 (PubMed).