Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1) Antikörper

Antigen: Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1)

Synonyme: VR1, DKFZp434K0220, Vr1, Vr1l1, VR.5'sv, VR-1, OTRPC1, TRPV1beta, TRPV1alpha, TRPV1, Trpv1

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Affe, Maus, Ratte (Rattus)

Applikation: Immunhistochemie (Gefrierschnitte) (IHC (fro)), Immunfluoreszenz (IF), Western Blot (WB)

Produktnummer: ABIN250444

Produktbeschreibung

Weitere Bezeichnung: TRPV1 / Vanilloid receptor 1

Immunogen: Synthetic peptide: RASLDSEESESPPQENSC, corresponding to amino-terminus of RatVR1, amino acids 4-21.

Format: Serum

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation ofburning pain by selectively activating sensory neurons that convey information aboutnoxious stimuli to the central nervous system. The protein encoded by this gene is areceptor for capsaicin and is a non-selective cation channel that is structurally related tomembers of the TRP family of ion channels. This receptor is also activated by increasesin temperature in the noxious range, suggesting that it functions as a transducer ofpainful thermal stimuli in vivo. Four transcript variants encoding the same protein, butwith different 5' UTR sequence, have been described for this gene. Alternate Names: anti-capsaicin receptor antibody, anti-DKFZp434K0220 antibody, anti-osm 9 like TRPchannel 1 antibody, anti-OTRPC1 antibody, anti-TRPV1 antibody, anti-Vanilloid receptorsubtype 1 antibody, anti-VR1 antibody.

Spezifität: Species Reactivity: Cross-reacts with Mouse, Rat and Non Human Primates. Not yet tested in otherspecies. Localization: Plasma membrane.

Anwendungen

Applikationshinweise: Suggested working dilutions: Western Blot 1/1000 ,Immunocytochemistry 1/1000,Immunohistochemistry-Frozen 1/1000. Positive Controls: VR1 transfected cells.

Buffer: Whole Serum. Preservative: 0.05% sodium azide.

Lagerung: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.

Forschungsgebiet: Rezeptoren, Signaltransduktion

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1) antibody

Publikationen

Publikationen: Caterina, Schumacher, Tominaga et al.: "The capsaicin receptor: a heat-activated ion channel in the pain pathway." in: Nature, Vol. 389, Issue 6653, pp. 816-24, 1997 (PubMed).

Guo, Vulchanova, Wang et al.: "Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites." in: The European journal of neuroscience, Vol. 11, Issue 3, pp. 946-58, 1999 (PubMed).

Stein, Ufret-Vincenty, Hua et al.: "Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane." in: The Journal of general physiology, Vol. 128, Issue 5, pp. 509-22, 2006 (PubMed).

Sappington, Calkins: "Contribution of TRPV1 to microglia-derived IL-6 and NFkappaB translocation with elevated hydrostatic pressure." in: Investigative ophthalmology & visual science, Vol. 49, Issue 7, pp. 3004-17, 2008 (PubMed).

Sappington, Sidorova, Long et al.: "TRPV1: contribution to retinal ganglion cell apoptosis and increased intracellular Ca2+ with exposure to hydrostatic pressure." in: Investigative ophthalmology & visual science, Vol. 50, Issue 2, pp. 717-28, 2009 (PubMed).