Aryl Hydrocarbon Receptor (AHR) Antikörper

Antigen: Aryl Hydrocarbon Receptor (AHR)

Synonyme: bHLHe76, AHR, Ah, In, Ahh, Ahre, ahr1, ahr, Ahr

Klonalität: Polyklonal

Wirt: Ziege

Reaktivität: Human, Maus

Applikation: Elektromobilitäts-Experimente (EMSA)

Produktnummer: ABIN249964

Produktbeschreibung

Weitere Bezeichnung: Ah receptor (AhR)

Gen-ID: 196, 11622

Immunogen: N-terminal sequence of the Ah receptor based on the Ah receptor purified fromC57BL/6J mice.

Format: Serum

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: The Ah Receptor belongs to a family of proteins comprised of its dimerization partnerARNT (HIF-1 Beta) and the Drosophila proteins PER and SIM. All of these proteinsshare an N-terminal sequence of ~200 amino acids termed the PAS domain. Thisreceptor, found in a variety of tissues, binds to a specific DNA enhancer sequence andinitiates transcription of the mRNA for the cytochrome P-450 (CYPIA1) gene. Alternate Names: anti-Dioxin Receptor antibody, Anti-AhR antibody.

Spezifität: This antibody is specific for AHR. Species Reactivity: Human and Mouse. Other species not tested.

Anwendungen

Applikationshinweise: Suggested working dilution for gel shift: add 4 microliter AhR-AB to a 15 ul final volumeof EMSA sample.Other applications have not been tested.

Buffer: Preservative: Sodium Azide.

Lagerung: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Forschungsgebiet: Transkriptionsfaktoren

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Poland, Glover, Bradfield: "Characterization of polyclonal antibodies to the Ah receptor prepared by immunization with a synthetic peptide hapten." in: Molecular pharmacology, Vol. 39, Issue 1, pp. 20-6, 1991 (PubMed).

Hayashibara, Yamada, Mori et al.: "Possible involvement of aryl hydrocarbon receptor (AhR) in adult T-cell leukemia (ATL) leukemogenesis: constitutive activation of AhR in ATL." in: Biochemical and biophysical research communications, Vol. 300, Issue 1, pp. 128-34, 2002 (PubMed).

Minsavage, Vorojeikina, Gasiewicz: "Mutational analysis of the mouse aryl hydrocarbon receptor tyrosine residues necessary for recognition of dioxin response elements." in: Archives of biochemistry and biophysics, Vol. 412, Issue 1, pp. 95-105, 2003 (PubMed).

Tsuchiya, Nakajima, Yokoi: "Critical enhancer region to which AhR/ARNT and Sp1 bind in the human CYP1B1 gene." in: Journal of biochemistry, Vol. 133, Issue 5, pp. 583-92, 2003 (PubMed).

Fisher, Nagarkatti, Nagarkatti: "Combined screening of thymocytes using apoptosis-specific cDNA array and promoter analysis yields novel gene targets mediating TCDD-induced toxicity." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 78, Issue 1, pp. 116-24, 2004 (PubMed).