ADAM Metallopeptidase Domain 17 (ADAM17) Antikörper

Antigen: ADAM Metallopeptidase Domain 17 (ADAM17)

Synonyme: CSVP, TACE, ADAM18, CD156B, MGC71942, Tace, CD156b, ADAM17, adam17, si:dkey-81b15.2

Klonalität: Polyklonal

Wirt: Ziege

Reaktivität: Human

Applikation: Enzyme Immunoassay (EIA), Western Blot (WB)

Produktnummer: ABIN249487

Produktbeschreibung

Weitere Bezeichnung: CD156b / ADAM17

Gen-ID: 6868

Swiss-Prot: NP_0031743

Immunogen: Synthetic peptide: LQRQNRVDSKETEC representing the C-terminus of the humanprotein (residues 811-824), according to NP_003174.3. Reference Sequence: NP_003174.3.

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain)family. Members of this family are membrane-anchored proteins structurally related tosnake venom disintegrins, and have been implicated in a variety of biologic processesinvolving cell-cell and cell-matrix interactions, including fertilization, muscledevelopment, and neurogenesis. The protein encoded by this gene functions as a tumornecrosis factor-alpha converting enzyme, binds mitotic arrest deficient 2 protein, andalso plays a prominent role in the activation of the Notch signaling pathway. Alternate Names: anti-A Disintegrin and Metalloproteinase Domain 1 antibody, anti-Snake venom likeprotease antibody, anti-TACE antibody, anti-TNF alpha converting enzyme antibody,anti-Tumor Necrosis Factor Alpha Converting Enzyme antibody, anti-ADAM17 antibody,anti-CSVP antibody, anti-CD1566 antibody, anti-MGC71942 antibody.

Spezifität: This antibody is expected to recognise isoform 1 (represented by NP_003174) and notisoform 2 (represented by NP_068604). Species Reactivity: Cross-reacts with Human. Expected to cross-react with Mouse, Rat and Chinese Hamster due to sequence homology. Not yet tested in other species. Localization: Type I membrane protein.

Anwendungen

Applikationshinweise: Suggested working dilutions: ELISA 1:128,000,Western Blot 0.1-0.3 ug/ml

Konzentration: 0.5 mg/ml

Buffer: Tris saline containing [pH7.3] with 0.5% BSA. Preservative: 0.02% Na azide.

Lagerung: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Forschungsgebiet: CD Antigene, Oberflächenrezeptoren der Immunzellen , Enzyme

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

ABIN249487 staining (0.2µg/ml) of Hela lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.