Coagulation Factor VIII (F8) Antikörper

Antigen: Coagulation Factor VIII (F8)

Synonyme: AHF, F8B, F8C, HEMA, FVIII, DXS1253E, F8, Cf8, Cf-8, fb61d02, wu:fb61d02

Klonalität: Polyklonal

Wirt: Huhn

Reaktivität: Human

Applikation: Immunhistochemie (IHC), ELISA

Produktnummer: ABIN249391

Produktbeschreibung

Immunogen: purified full length native human Coagulation Factor VIII-VWF-F VIII:c complex

Format: Liquid

Beschreibung: The factor VIII complex, with a molecular weight in excess of 1 million, has 2components: (1) factor VIII P00451 (molecular weight of 267 kDa) called factorVIII C, when measured by procoagulant activity or factor VIII Ag, when measuredimmunologically, (2) factor VIII R P04275 (the von Willebrand factor or vWF) hasa molecular weight of 225 kDa. Factor VIII, along with calcium and phospholipids,acts as a cofactor for factor IXa when it converts factor X to the activated form,factor Xa. Domain F5/8 type C 2 Is responsible for phospholipid binding andessential for factor VIII activity. Defects in F8 are the cause of hemophilia A (HEMA). HEMA is a common recessive X-linked coagulation disorder.

Spezifität: Predicted reactivity: human.

Anwendungen

Applikationshinweise: Recommended Dilution 1: 200 (IHC).

Konzentration: IgG concentration is 22.2 µg/µl

Buffer: Total IgY fraction at 20 mg/ml in 0.9% NaCl, 0.1% sodiumazide

Lagerung: store at 4°C, make aliquots to avoid working with a stock. Please, remember tospin tubes briefly prior to opening them to avoid any losses that might occur fromliquid material adhering to the cap or sides of the tubes.

Beschränkungen: Nur für Forschungszwecke einsetzbar