RUNX1T1 Antikörper (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related)) (N-Term)

Details for Product anti-RUNX1T1 Antibody No. ABIN2486989, Anbieter: Anmelden zum Anzeigen
Antigen
  • MTG8
  • si:ch211-232j17.1
  • wu:fi14b07
  • zgc:154044
  • AML1T1
  • CBFA2T1
  • CDR
  • ETO
  • ZMYND2
  • Cbfa2t1h
  • Cbfa2t1
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
  • runx1t1
  • RUNX1T1
  • Runx1t1
Epitop
N-Term
4
4
3
3
2
2
2
1
1
1
1
1
Reaktivität
Human
38
18
15
9
7
6
6
5
5
5
4
3
3
1
1
Wirt
Kaninchen
29
9
Klonalität
Polyklonal
Applikation
Chromatin Immunoprecipitation (ChIP), ELISA
29
14
7
6
2
2
1
1
Optionen
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Verwendungszweck Polyclonal Antibody to detect ETO in human samples.
Immunogen Polyclonal antibody against human ETO using two KLH-conjugated synthetic peptides containing sequences from the N-terminal and the central region of the protein, respectively.
Isotyp IgG
Produktmerkmale Polyclonal Antibody to detect ETO in human samples.
Reinigung Whole Anti-Sera
Andere Bezeichnung ETO (RUNX1T1 Antibody Abstract)
Hintergrund ETO is a transcriptional regulator which belongs to the myeloid translocation gene family. ETO exerts its function by interaction with transcription factors bound to promoters and binding to histone deacetylases. It recruits a range of corepressors to facilitate transcriptional repression. The t (8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. This translocation produces a chimeric gene made up of the 5'-region of AML1 and the 3'-region of the ETO gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation.
Synonyms: RUNX1T1, AML1T1, CBFA2T1, CDR, MTG8, ZMYND2
Gen-ID 862
UniProt Q06455
Applikationshinweise ChIP: 4 μL/ChIP, ELISA: 1:100.
Kommentare

Suggested positive control:
ELISA: Peptides, ChIP: SKNO-1 cells.

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer In PBS with 0.05 % (W/V) sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung The antibody solution should be gently mixed before use.
Lagerung -20 °C
Haltbarkeit 12 months
Bilder des Herstellers
Chromatin Immunoprecipitation (ChIP) image for anti-RUNX1T1 Antikörper (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related)) (N-Term) (ABIN2486989) anti-Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) (N-Term) antibody
ELISA image for anti-RUNX1T1 Antikörper (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related)) (N-Term) (ABIN2486989) anti-Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) (N-Term) antibody (Image 2)