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SCNN1A Antikörper (AA 629-650) (Alkaline Phosphatase (AP))

SCNN1A Reaktivität: Ratte WB, IHC, IF, ICC Wirt: Kaninchen Polyclonal Alkaline Phosphatase (AP)
Produktnummer ABIN2486425
  • Target Alle SCNN1A Antikörper anzeigen
    SCNN1A (Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A))
    Bindungsspezifität
    • 63
    • 22
    • 21
    • 10
    • 10
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 629-650
    Reaktivität
    • 99
    • 45
    • 39
    • 20
    • 10
    Ratte
    Wirt
    • 82
    • 43
    Kaninchen
    Klonalität
    • 82
    • 43
    Polyklonal
    Konjugat
    • 28
    • 11
    • 10
    • 10
    • 10
    • 10
    • 9
    • 9
    • 9
    • 9
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SCNN1A Antikörper ist konjugiert mit Alkaline Phosphatase (AP)
    Applikation
    • 115
    • 103
    • 36
    • 35
    • 34
    • 21
    • 10
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    Detects ~83 kDa.
    Kreuzreaktivität
    Hamster, Human, Maus, Ratte, Xenopus laevis
    Aufreinigung
    Protein A Purified
    Immunogen
    Produced against the C-terminal tail (amino acids 629-650) of rat gamma ENaC (antibody designation L550)
    Top Product
    Discover our top product SCNN1A Primärantikörper
  • Applikationshinweise
    • WB (1:1000)
    • IHC (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    1 μg/ml of ABIN2486425 was sufficient for detection of gamma-ENaC in 20 μg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Conjugated antibodies should be stored at 4°C
  • Target
    SCNN1A (Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A))
    Andere Bezeichnung
    ENaC (SCNN1A Produkte)
    Synonyme
    BESC2 antikoerper, ENaCa antikoerper, ENaCalpha antikoerper, SCNEA antikoerper, SCNN1 antikoerper, ENaC antikoerper, Scnn1 antikoerper, mENaC antikoerper, SCNN1A antikoerper, alphaxENaC antikoerper, besc2 antikoerper, enaca antikoerper, scnn1 antikoerper, ENAC antikoerper, sodium channel epithelial 1 alpha subunit antikoerper, sodium channel, nonvoltage-gated 1 alpha antikoerper, sodium channel, non voltage gated 1 alpha subunit L homeolog antikoerper, Scnn1a antikoerper, SCNN1A antikoerper, scnn1a.L antikoerper
    Hintergrund
    The Epithelial Sodium Channel (ENaC) is a membrane ion channel permeable to Na+ ions. It is located in the apical plasma membrane of epithelia in the kidneys, lung, colon, and other tissues where it plays a role in trans epithelial Na+-ion transport (1). Specifically Na+ transport via ENaC occurs across many epithelial surfaces, and plays a key role in regulating salt and water absorption (2). ENaCs are composed of three structurally related subunits that form a tetrameric channel, α, β, and γ. The expression of its alpha and beta subunits is enhanced as keratinocytes differentiate (3, 4). The beta and gamma-ENaC subunits are essential for edema fluid to exert its maximal effect on net fluid absorption by distal lung epithelia(5). And it has been concluded that the subunits are differentially expressed in the retina of mice with ocular hypertension, therefore the up-regulation of alpha-ENaC proteins could serve as a protection mechanism against elevated intraocular pressure (6).
    Gen-ID
    24768
    NCBI Accession
    NP_058742
    UniProt
    P37091
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